Department of Orthopedics, The Fourth Medical Center of Chinese PLA General Hospital, Beijing, China; National Clinical Research Center for Orthopedics, Sports Medicine and Rehabilitation, Beijing, China; Department of Orthopedics, Air Force Medical Center, PLA, Beijing, China.
Department of Orthopedics, The Fourth Medical Center of Chinese PLA General Hospital, Beijing, China; National Clinical Research Center for Orthopedics, Sports Medicine and Rehabilitation, Beijing, China; School of Life Sciences, Tsinghua University, Beijing, China; State Key Laboratory of Precision Measurement Technology and Instruments, Department of Precision Instruments, Tsinghua University, Beijing, China; IDG/McGovern Institute for Brain Research, Tsinghua University, Beijing, China.
Exp Neurol. 2023 Dec;370:114570. doi: 10.1016/j.expneurol.2023.114570. Epub 2023 Oct 16.
Spinal cord injury (SCI) is a debilitating condition that is frequently accompanied by neuropathic pain, resulting in significant physical and psychological harm to a vast number of individuals globally. Despite the high prevalence of neuropathic pain following SCI, the precise underlying mechanism remains incompletely understood. Microglia are a type of innate immune cell that are present in the central nervous system (CNS). They have been observed to have a significant impact on neuropathic pain following SCI. This article presents a comprehensive overview of recent advances in understanding the role of microglia in the development of neuropathic pain following SCI. Specifically, the article delves into the detrimental and protective effects of microglia on neuropathic pain following SCI, as well as the mechanisms underlying their interconversion. Furthermore, the article provides a thorough overview of potential avenues for future research in this area.
脊髓损伤（SCI）是一种使人虚弱的疾病，常伴有神经性疼痛，给全球大量个人带来严重的身体和心理伤害。尽管 SCI 后神经性疼痛的患病率很高，但确切的潜在机制仍不完全清楚。小胶质细胞是一种存在于中枢神经系统（CNS）中的先天免疫细胞。已经观察到它们对 SCI 后神经性疼痛有重大影响。本文全面介绍了理解小胶质细胞在 SCI 后神经性疼痛发展中的作用的最新进展。具体来说，文章深入探讨了小胶质细胞对 SCI 后神经性疼痛的有害和保护作用，以及它们相互转化的机制。此外，本文还全面概述了该领域未来研究的潜在途径。
