Renner H W
Mutat Res. 1986 Dec;172(3):265-9. doi: 10.1016/0165-1218(86)90064-9.
To test for possible anticlastogenic effects of fatty acids, the methyl esters of fatty acids--short-chain to long-chain--were examined on busulfan in Chinese hamster bone-marrow cells using the chromosome aberration test. When the experimental animals were treated with fatty acid esters and the mutagen, the chromosome-breaking actions of busulfan were not modulated by the short-chain fatty acids, but the fatty acids from lauric acid (C12) up to nonadecanoic acid (C19) reduced the rate of aberrant metaphases from 9.4 to about 3% at doses of 100 mg/kg and less. Other chemical properties of the fatty acids (saturated or not, number of double bonds, even- or odd-numbered) had no influence on the anticlastogenic effects. The only exceptions to this rule were arachidonic acid, which had no effect, and gamma-linolenic acid, which had no consistent effect on the action of busulfan.
为检测脂肪酸可能的抗致断裂效应，使用染色体畸变试验，在中国仓鼠骨髓细胞中，对短链至长链的脂肪酸甲酯进行了关于白消安的研究。当用脂肪酸酯和诱变剂处理实验动物时，短链脂肪酸未调节白消安的染色体断裂作用，但月桂酸（C12）至十九烷酸（C19）的脂肪酸在剂量为100mg/kg及以下时，可将异常中期细胞率从9.4%降至约3%。脂肪酸的其他化学性质（是否饱和、双键数量、偶数或奇数碳链）对抗致断裂效应无影响。该规则的唯一例外是花生四烯酸，其无作用，以及γ-亚麻酸，其对白消安的作用无一致影响。
