Department of Nutrition and Food Hygiene, College of Public Health, Xinjiang Medical University, Urumqi, 830011, China.
Sci Rep. 2023 Oct 18;13(1):17718. doi: 10.1038/s41598-023-43550-8.
Obesity can be categorized as metabolically healthy obesity (MHO) and metabolically unhealthy obesity (MUO). However, individuals with MHO are characterized by the absence of metabolic syndrome (MS) and appear to have lower inflammation levels compared to MUO. This study aimed to investigate the association of obesity phenotypes with leptin (LEP) and adiponectin (ADP). According to the inclusion and exclusion criteria, we selected 178 subjects from the previous cross-sectional survey. Based on the body mass index (BMI) and diagnostic criteria of MS, we divided the individuals into three groups, including healthy control group (HC group), metabolically healthy obesity group (MHO group) and metabolically unhealthy obesity group (MUO group). The concentrations of LEP and ADP in serum were measured, and the association of these two cytokines with different obesity phenotypes were subsequently analyzed. Compared to both the HC and MHO groups, the MUO group showed significantly higher BMI, waist circumference (WC), waist-hip ratio (WHR), triglyceride (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), fasting plasma glucose (FPG), homeostasis model assessment of insulin resistance (Homa-IR) and blood pressure (P < 0.05). In contrast, serum high-density lipoprotein cholesterol (HDL-C) was notably lower in the MUO group (P < 0.05). ADP was found to have a positive correlation with systolic blood pressure (SBP) and a negative correlation with FPG in the MHO group. In the MUO group, LEP demonstrated a positive correlation with fasting insulin (FINS) and Homa-IR, while ADP showed a positive correlation with TC and SBP. Linear regression analysis further indicated that SBP (β = 0.234, P = 0.043), TG (β = - 0.292, P = 0.001) and LDL-C (β = 0.626, P = 0.000) were independently correlated with ADP, and BMI (β = 0.398, P = 0.002) was independently correlated with LEP in obese individuals. In conclusion, ADP and LEP were closely related with glucose and lipid metabolism in obese individuals, these two cytokines might play critical roles in obesity-associated metabolic disorders.
肥胖可以分为代谢健康型肥胖（MHO）和代谢不健康型肥胖（MUO）。然而，MHO 患者的特点是没有代谢综合征（MS），并且与 MUO 相比，他们的炎症水平似乎更低。本研究旨在探讨肥胖表型与瘦素（LEP）和脂联素（ADP）的关系。根据纳入和排除标准，我们从之前的横断面研究中选择了 178 名受试者。根据体重指数（BMI）和 MS 的诊断标准，我们将个体分为三组，包括健康对照组（HC 组）、代谢健康型肥胖组（MHO 组）和代谢不健康型肥胖组（MUO 组）。测量血清中 LEP 和 ADP 的浓度，随后分析这两种细胞因子与不同肥胖表型的关系。与 HC 组和 MHO 组相比，MUO 组的 BMI、腰围（WC）、腰臀比（WHR）、甘油三酯（TG）、总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）、空腹血糖（FPG）、胰岛素抵抗指数（Homa-IR）和血压（BP）明显更高（P<0.05）。相反，MUO 组血清高密度脂蛋白胆固醇（HDL-C）明显降低（P<0.05）。在 MHO 组中，ADP 与收缩压（SBP）呈正相关，与 FPG 呈负相关。在 MUO 组中，LEP 与空腹胰岛素（FINS）和 Homa-IR 呈正相关，而 ADP 与 TC 和 SBP 呈正相关。线性回归分析进一步表明，SBP（β=0.234，P=0.043）、TG（β=-0.292，P=0.001）和 LDL-C（β=0.626，P=0.000）与 ADP 独立相关，而 BMI（β=0.398，P=0.002）与肥胖个体的 LEP 独立相关。综上所述，ADP 和 LEP 与肥胖个体的糖脂代谢密切相关，这两种细胞因子可能在肥胖相关的代谢紊乱中发挥关键作用。
