Department of Biological Sciences, Faculty of Science, Beirut Arab University, Beirut, Lebanon.
Rammal Hassan Rammal Research Laboratory, PhyToxE Research Group, Faculty of Sciences Section V, Lebanese University, Nabih Berri Street, Nabatieh, Lebanon.
Sci Rep. 2023 Oct 18;13(1):17806. doi: 10.1038/s41598-023-44814-z.
The current study investigated the effects of 24 h/day prenatal exposure to global system for mobile communication electromagnetic fields (GSM-EMFs), 900 MHZ-induced electromagnetic radiation (EMR), on oxidative stress (OS) status, apoptotic, and inflammatory changes in liver of rats during their fetal development period. Fifty-two Sprague-Dawley pregnant rats were equally divided into control and exposed groups. Whole embryos were removed at 7.5 dpc (days post coitus), while liver tissues were extracted from embryos at 11.5, 15.5, and 19.5 dpc. For exposed animals, results showed an increased OS reflected by high levels of malondialdehyde (MDA), a decrease in cytosolic superoxide dismutase (cytoSOD) activity, in mitochondrial superoxide dismutase (mitoSOD) levels and catalase (CAT) mRNA expression but also in hepatic nuclear factor erythroïd 2-related Factor 2 (Nrf-2), protein kinase B (Akt1), and intercellular adhesion molecule-1 (ICAM-1) mRNA expression at 15.5 dpc. Moreover, GSM-EMR exposure was shown to significantly decrease mitoSOD and CAT activities at almost all studied ages. Thus, rat embryos may be protected by their mothers from OS, apoptotic, and pro-inflammatory responses till a sensitive developmental stage, during a continuous prenatal EMR exposure. This protection could be then created from the embryos themselves.
本研究旨在探讨大鼠胚胎发育期 24 小时/天暴露于全球移动通信系统（GSM）电磁场（900MHz 电磁辐射）下对氧化应激（OS）状态、凋亡和炎症变化的影响。52 只 Sprague-Dawley 孕鼠等分为对照组和暴露组。在妊娠第 7.5 天（交配后）取出全胚胎，在妊娠第 11.5、15.5 和 19.5 天取出肝组织。对于暴露组动物，结果显示 OS 增加，表现为丙二醛（MDA）水平升高、胞浆超氧化物歧化酶（cytoSOD）活性降低、线粒体超氧化物歧化酶（mitoSOD）水平和过氧化氢酶（CAT）mRNA 表达降低，同时肝细胞核因子 2 相关因子 2（Nrf-2）、蛋白激酶 B（Akt1）和细胞间黏附分子 1（ICAM-1）mRNA 表达也降低。此外，GSM-EMR 暴露在几乎所有研究的年龄都显著降低了 mitoSOD 和 CAT 的活性。因此，在持续的产前 EMR 暴露下，胚胎可能会受到母亲的保护，免受 OS、凋亡和促炎反应的影响。这种保护可能是由胚胎自身产生的。
