Department of Occupational Health and Safety, Health School of Muş Alparslan University, Muş, Turkey.
Department of Biophysics, Medical School of Dicle University, Diyarbakir, Turkey.
Bioelectromagnetics. 2021 Jan;42(1):76-85. doi: 10.1002/bem.22315. Epub 2020 Dec 25.
The continuously increasing usage of cell phones has raised concerns about the adverse effects of microwave radiation (MWR) emitted by cell phones on health. Several in vitro and in vivo studies have claimed that MWR may cause various kinds of damage in tissues. The aim of this study is to examine the possible effects of exposure to low-intensity MWR on DNA and oxidative damage in the livers of rats. Eighteen Sprague-Dawley male rats were divided into three equal groups randomly (n = 6). Group 1 (Sham-control): rats were kept under conditions the same as those of other groups, except for MWR exposure. Group 2: rats exposed to 1800 MHz (SAR: 0.62 W/kg) at 0.127 ± 0.04 mW/cm power density, and Group 3: rats exposed to 2,100 MHz (SAR: 0.2 W/kg) at 0.038 ± 0.03 mW/cm power density. Microwave application groups were exposed to MWR 2 h/day for 7 months. At the end of the exposure period, the rats were sacrificed and DNA damage, malondialdehyde (MDA), 8-hydroxydeoxyguanosine (8-OHdG), and total oxidant-antioxidant parameter analyses were conducted in their liver tissue samples. It was found that 1800 and 2100 MHz low-intensity MWR caused a significant increase in MDA, 8-OHdG, total oxidant status, oxidative stress index, and comet assay tail intensity (P < 0.05), while total antioxidant status levels (P < 0.05) decreased. The results of our study showed that whole-body exposure to 1800 and 2100 MHz low-intensity MWR emitted by cell phones can induce oxidative stress by altering oxidant-antioxidant parameters and lead to DNA strand breaks and oxidative DNA damage in the liver of rats. Bioelectromagnetics. 2021;42:76-85. © 2020 Bioelectromagnetics Society.
手机的使用不断增加，人们对手机发出的微波辐射（MWR）对健康的不良影响表示担忧。一些体外和体内研究声称，MWR 可能会导致组织的各种损伤。本研究旨在检查低强度 MWR 暴露对大鼠肝脏 DNA 和氧化损伤的可能影响。将 18 只 Sprague-Dawley 雄性大鼠随机分为三组（n=6）。第 1 组（假对照）：大鼠保持与其他组相同的条件，除了不接受 MWR 暴露。第 2 组：暴露于 1800MHz（SAR：0.62W/kg），功率密度为 0.127±0.04mW/cm。第 3 组：暴露于 2100MHz（SAR：0.2W/kg），功率密度为 0.038±0.03mW/cm。微波应用组每天暴露于 MWR 2 小时，持续 7 个月。暴露期结束时，处死大鼠，对其肝组织样本进行 DNA 损伤、丙二醛（MDA）、8-羟基脱氧鸟苷（8-OHdG）和总氧化剂-抗氧化剂参数分析。结果发现，1800MHz 和 2100MHz 低强度 MWR 导致 MDA、8-OHdG、总氧化剂状态、氧化应激指数和彗星试验尾部强度显著增加（P<0.05），而总抗氧化状态水平降低（P<0.05）。我们的研究结果表明，手机发射的 1800MHz 和 2100MHz 低强度全身 MWR 暴露可通过改变氧化剂-抗氧化剂参数诱导氧化应激，导致大鼠肝脏 DNA 链断裂和氧化 DNA 损伤。生物电磁学。2021；42:76-85。©2020 生物电磁学学会。
