Baertl Susanne, Renz Nora, Alt Volker, Perka Carsten, Kirschbaum Stephanie
Centrum für Muskuloskeletale Chirurgie, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Deutschland.
Klinik und Poliklinik für Unfallchirurgie, Universitätsklinikum Regensburg, Regensburg, Deutschland.
Unfallchirurgie (Heidelb). 2024 Feb;127(2):110-116. doi: 10.1007/s00113-023-01376-z. Epub 2023 Oct 18.
Acute periprosthetic joint infections (PJI) after dual head arthroplasty represent a major challenge with a 1-year mortality rate up to 50% in the mostly multimorbid geriatric patient collective. Due to the limited possibilities of preoperative patient optimization, infection rates of up to 9% have been reported, which is significantly higher than in elective arthroplasty. A therapeutic gold standard has not yet been established due to the heterogeneous study situation and the lack of prospective randomized studies. The most promising therapeutic option currently appears to be a single-stage stem replacement in combination with implantation of a cup component (conversion to total hip arthroplasty, infection eradication in up to 100%). An approach of débridement, antibiotics, implant retention (DAIR) alone shows significantly poorer success rates (16-82%). Surgical treatment should always be followed by antibiotic treatment with a total duration of 12 weeks. In addition to the established perioperative antibiotic prophylaxis, the use of antibiotic-loaded bone cement seems to be superior to cementless stem fixation in preventing PJI in dual head arthroplasty.
双头关节置换术后的急性人工关节周围感染(PJI)是一项重大挑战,在大多患有多种疾病的老年患者群体中,1年死亡率高达50%。由于术前优化患者的可能性有限,已报告的感染率高达9%,这明显高于择期关节置换术。由于研究情况参差不齐且缺乏前瞻性随机研究,尚未确立治疗金标准。目前最有前景的治疗选择似乎是一期柄部置换联合髋臼组件植入(转换为全髋关节置换术,感染根除率高达100%)。单纯的清创、抗生素、保留植入物(DAIR)方法成功率明显较低(16 - 82%)。手术治疗后应始终进行为期12周的抗生素治疗。除了已确立的围手术期抗生素预防措施外,在预防双头关节置换术中的PJI方面,使用含抗生素骨水泥似乎优于无水泥柄固定。