Amity Institute of Biotechnology, Amity University Uttar Pradesh Lucknow Campus, Lucknow, Uttar Pradesh, India.
Cell Biochem Biophys. 2024 Mar;82(1):91-105. doi: 10.1007/s12013-023-01191-8. Epub 2023 Oct 19.
Toll-like receptors are important molecules of innate immunity. They are known as pattern recognition receptors. They recognise certain molecules known as pathogen-associated molecular pattern on a pathogen and release chemicals that causes inflammation. Toll-like receptors (TLR) help in the removal of the infected cell and thus stop the spread of infection and are being studied for their association with cancer. Oral carcinoma has emerged as a major problem of our country today; it is found ranks first in men and third in women. Toll-like receptors have been implicated in the development of cancer. Certain polymorphisms in toll-like receptor can make a cell more susceptible to develop oral cancer. The identification of toll-like receptors and the different genotypes that are involved in the development of cancer can be utilised for using them as biomarkers of the disease. The study revealed that toll-like receptors like TLR7 and TLR5 are found to have a role in suppression of oral cancer while toll-like receptors like TLR4 and TLR2 are found to be associated with the progression of oral cancer. Toll-like receptors can turn out as important target molecules in the future in designing therapeutic strategies for oral cancer.
Toll 样受体是先天免疫系统的重要分子。它们被称为模式识别受体。它们可以识别病原体上某些已知的病原体相关分子模式，并释放引起炎症的化学物质。Toll 样受体 (TLR) 有助于清除感染细胞，从而阻止感染的传播，并因其与癌症的关联而受到研究。口腔癌已成为我国当今的一个主要问题；在男性中排名第一，在女性中排名第三。Toll 样受体被认为与癌症的发展有关。Toll 样受体的某些多态性使细胞更容易发生口腔癌。鉴定 Toll 样受体以及参与癌症发展的不同基因型，可以将其用作疾病的生物标志物。研究表明，TLR7 和 TLR5 等 Toll 样受体在抑制口腔癌方面发挥作用，而 TLR4 和 TLR2 等 Toll 样受体与口腔癌的进展有关。Toll 样受体将来可能成为设计口腔癌治疗策略的重要靶分子。
