Hospital of Stomatology, Jilin University, Changchun, 130021, People's Republic of China.
Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, People's Republic of China.
Eur J Med Res. 2022 Oct 8;27(1):198. doi: 10.1186/s40001-022-00835-4.
Oral cancer is one of the most common malignant tumors of the head and neck, not only affects the appearance, but also affects eating and even endangers life. The clinical treatments of oral cancer mainly include surgery, radiotherapy, and chemotherapy. However, unsatisfactory therapeutic effect and toxic side effects are still the main problems in clinical treatment. Tumor microenvironment (TME) is not only closely related to the occurrence, growth, and metastasis of tumor but also works in the diagnosis, prevention, and treatment of tumor and prognosis. Future studies should continue to investigate the relationship of TME and oral cancer therapy. This purpose of this review was to analyze the characteristics of oral cancer microenvironment, summarize the traditional oral cancer therapy and immunotherapy strategies, and finally prospect the development prospects of oral cancer immunotherapy. Immunotherapy targeting tumor microenvironment is expected to provide a new strategy for clinical treatment of oral cancer.
口腔癌是头颈部最常见的恶性肿瘤之一，不仅影响外观，还影响进食，甚至危及生命。口腔癌的临床治疗主要包括手术、放疗和化疗。然而，不尽如人意的治疗效果和毒副作用仍然是临床治疗中的主要问题。肿瘤微环境（TME）不仅与肿瘤的发生、生长和转移密切相关，而且在肿瘤的诊断、预防和治疗以及预后中也起着重要作用。未来的研究应继续探讨 TME 与口腔癌治疗的关系。本综述旨在分析口腔癌微环境的特征，总结传统的口腔癌治疗和免疫治疗策略，最后展望口腔癌免疫治疗的发展前景。靶向肿瘤微环境的免疫治疗有望为口腔癌的临床治疗提供新策略。
