Department of Psychiatry and Health Behavior, Medical College of Georgia, Augusta University, Augusta, Georgia.
Department of Psychiatry and Health Behavior, Medical College of Georgia, Augusta University, Augusta, Georgia.
Prog Neuropsychopharmacol Biol Psychiatry. 2021 Dec 20;111:110202. doi: 10.1016/j.pnpbp.2020.110202. Epub 2020 Dec 4.
Insomnia occurs frequently in the clinical course of schizophrenia. A growing literature has found associations between insomnia, suicidal ideation, and psychopathology in patients with schizophrenia. We explored these associations in a cross-sectional study of a large sample of patients with chronic schizophrenia in China. We hypothesized that insomnia would be associated with an increased odds of current suicidal ideation and higher current psychopathology scores.
We recruited 328 inpatients with chronic schizophrenia, all of whom were prescribed psychotropics. We investigated relationships between current insomnia, suicidal ideation over the past two weeks, and current psychopathology for subjects using regression models.
After controlling for multiple potential confounding factors, current insomnia was an indicator of a significant, 2.5-fold increased odds of suicidal ideation (OR = 2.56, 95% CI 1.10-5.95, p = 0.029). Insomnia was also a significant indicator of lifetime suicide attempt (OR = 1.07) as well as higher Positive and Negative Syndrome Scale total (β = 0.134, p = 0.017), positive (β = 0.154, p = 0.006) and general (β = 0.145, p = 0.010) subscale scores.
Insomnia is associated with suicidal ideation, lifetime suicide attempt, and higher psychopathology scores in inpatients with chronic schizophrenia. Formal assessment of insomnia appears relevant to the clinical care of patients with schizophrenia as an indicator of suicidal thinking and behavior, depression, and symptom severity.
失眠在精神分裂症的临床过程中很常见。越来越多的文献发现失眠、自杀意念和精神病理学之间存在关联，在精神分裂症患者中。我们在中国一项对大量慢性精神分裂症患者的横断面研究中探讨了这些关联。我们假设失眠与当前自杀意念的可能性增加和当前精神病理学评分升高有关。
我们招募了 328 名慢性精神分裂症住院患者，他们都服用了精神药物。我们使用回归模型调查了受试者当前失眠、过去两周内自杀意念以及当前精神病理学之间的关系。
在控制了多个潜在的混杂因素后，当前失眠是自杀意念显著增加 2.5 倍的指标（OR=2.56，95%CI 1.10-5.95，p=0.029）。失眠也是终生自杀企图的重要指标（OR=1.07）以及阳性和阴性综合征量表总分（β=0.134，p=0.017）、阳性（β=0.154，p=0.006）和一般（β=0.145，p=0.010）分量表得分较高。
失眠与慢性精神分裂症住院患者的自杀意念、终生自杀企图和更高的精神病理学评分有关。对失眠进行正式评估似乎与精神分裂症患者的临床护理相关，因为它是自杀思维和行为、抑郁和症状严重程度的指标。
