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亚洲蝮属蛇类(Gloydius)咬伤犬的血栓弹性描记评估。

Thromboelastographic evaluation in dogs with Asian pit viper (Gloydius) envenomation.

机构信息

Korea Animal Medical Center, Cheongju, South Korea.

College of Veterinary Medicine, Chungnam National University, Daejeon, South Korea.

出版信息

J Vet Med Sci. 2023 Nov 18;85(11):1226-1230. doi: 10.1292/jvms.23-0100. Epub 2023 Oct 19.

DOI:10.1292/jvms.23-0100
PMID:37853633
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10686768/
Abstract

The objective of this study was to investigate the thromboelastography (TEG) variables and platelet count after Asian pit viper (Gloydius) envenomation in dogs compared with healthy control dogs. Ten dogs with snake envenomation and twenty healthy dogs were included. There was a significant decrease in G (P=0.017), maximum amplitude (MA) (P=0.012), angle value (P=0.041), platelet count (P<0.001, as well as an increase in K value (P=0.034) and R value (P=0.007) in dogs with snake envenomation. The results of this study revealed that dogs with Asian pit viper (Gloydius) envenomation showed a hypocoagulable state compared with healthy dogs. Our findings may support the use of TEG for diagnosing and monitoring coagulopathy after Asian pit viper (Gloydius) envenomation in dogs.

摘要

本研究旨在探讨亚洲蝮蛇(Gloydius)咬伤犬的血栓弹力图(TEG)变量和血小板计数与健康对照犬的比较。纳入 10 只蛇咬伤犬和 20 只健康犬。蛇咬伤犬的 G 值(P=0.017)、最大振幅(MA)(P=0.012)、角度值(P=0.041)、血小板计数(P<0.001)显著降低,K 值(P=0.034)和 R 值(P=0.007)升高。本研究结果表明,与健康犬相比,亚洲蝮蛇(Gloydius)咬伤犬表现出低凝状态。我们的发现可能支持 TEG 用于诊断和监测亚洲蝮蛇(Gloydius)咬伤犬后的凝血功能障碍。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f97b/10686768/8060b3b8a2cf/jvms-85-1226-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f97b/10686768/8060b3b8a2cf/jvms-85-1226-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f97b/10686768/8060b3b8a2cf/jvms-85-1226-g001.jpg

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本文引用的文献

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J Vet Sci. 2022 Nov;23(6):e81. doi: 10.4142/jvs.22105. Epub 2022 Sep 8.
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A Retrospective Evaluation of Snake Envenomation in Dogs in South Korea (2004-2021).韩国 2004-2021 年犬类蛇伤回顾性评估
Toxins (Basel). 2022 Aug 18;14(8):565. doi: 10.3390/toxins14080565.
3
Hemostatic Analysis of Simulated Envenomation Using Canine Blood: A Comparison of Thromboelastography and Classical Coagulation Tests.使用犬类血液对模拟中毒进行止血分析:血栓弹力图与传统凝血试验的比较
Animals (Basel). 2022 Jan 18;12(3):226. doi: 10.3390/ani12030226.
4
Snakebite Associated Thrombotic Microangiopathy and Recommendations for Clinical Practice.蛇咬伤相关性血栓性微血管病及临床实践建议。
Toxins (Basel). 2022 Jan 14;14(1):57. doi: 10.3390/toxins14010057.
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Snakebite envenomings in the Republic of Korea from the 1970s to the 2020s: A review.20 世纪 70 年代至 21 世纪 20 年代韩国的蛇咬伤:综述。
Toxicon. 2021 Jun;196:8-18. doi: 10.1016/j.toxicon.2021.03.013. Epub 2021 Mar 26.
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Coagulopathy after snake envenomation in South Korea.韩国蛇咬伤后的凝血功能障碍。
Clin Toxicol (Phila). 2021 Oct;59(10):905-912. doi: 10.1080/15563650.2021.1884694. Epub 2021 Mar 1.
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Adverse Reactions after Administration of Antivenom in Korea.韩国抗蛇毒血清治疗后的不良反应。
Toxins (Basel). 2020 Aug 6;12(8):507. doi: 10.3390/toxins12080507.
8
Novel Treatment Strategy for Patients with Venom-Induced Consumptive Coagulopathy from a Pit Viper Bite.一种新型治疗策略用于治疗响尾蛇咬伤引起的消耗性凝血障碍患者
Toxins (Basel). 2020 May 5;12(5):295. doi: 10.3390/toxins12050295.
9
Clinical implications of coagulotoxic variations in Mamushi (Viperidae: Gloydius) snake venoms.临床上蚂蟥(蝰蛇科:Gloydius)蛇毒的凝血毒性变化的意义。
Comp Biochem Physiol C Toxicol Pharmacol. 2019 Nov;225:108567. doi: 10.1016/j.cbpc.2019.108567. Epub 2019 Jul 12.
10
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