Department of Orthodontics, Osaka Dental University.
Department of Biomaterials, Osaka Dental University.
Dent Mater J. 2023 Nov 29;42(6):851-859. doi: 10.4012/dmj.2023-112. Epub 2023 Oct 17.
This study radiologically and histologically compared two bioresorbable bone substitutes with different compositions carbonate apatite (Cytrans Granules; CGs) and β-tricalcium phosphate (β-TCP) for vertical bone augmentation on a rat skull using a polytetrafluoroethylene (PTFE) tubes. This PTFE tube was placed at the center of the skull, fixed with Super Bond, and augmented with CGs or β-TCP granules. Specimens with surrounding tissue were harvested at 4, 8, and 12 weeks postoperatively, and radiological and histological evaluations were performed. The bone volume to total volume ratio (BV/TV) of the β-TCP-implanted group was markedly higher than that of the CG-implanted group at 4 and 12 weeks postoperatively. Compared to CGs, β-TCP exhibited the ability to form blood vessels into the graft material for a short period after transplantation, as well as an elevated production of collagen into β-TCP granules during the bone formation process.
本研究通过聚四氟乙烯（PTFE）管，在大鼠颅骨上进行垂直骨增量，比较了两种具有不同成分的生物可吸收骨替代物——碳酸磷灰石（Cytrans 颗粒；CGs）和 β-磷酸三钙（β-TCP）的影像学和组织学表现。PTFE 管置于颅骨中央，用 Super Bond 固定，并用 CGs 或 β-TCP 颗粒进行增量。术后 4、8 和 12 周时采集带有周围组织的标本，进行影像学和组织学评估。术后 4 周和 12 周时，β-TCP 植入组的骨体积与总体积比值（BV/TV）明显高于 CG 植入组。与 CGs 相比，β-TCP 具有在移植后短时间内将血管形成到移植物材料中的能力，并且在骨形成过程中，β-TCP 颗粒内的胶原产量增加。
