From the Laboratory of Pesticide Environmental Assessment and Pollution Control, Nanjing Institute of Environmental Sciences, Ministry of Ecology and Environment (MEE), Nanjing, People's Republic of China.
J Occup Environ Med. 2024 Feb 1;66(2):105-110. doi: 10.1097/JOM.0000000000003000. Epub 2023 Oct 19.
The present study aims to explore the relationship between perfluoroalkyl substances (PFAS) exposure and hyperlipidemia using data from the National Health and Nutrition Examination Survey.
A total of 1600 subjects were included in the analysis, and nine kinds of PFAS were measured. Multivariate logistic regression analysis was performed to explore the association between serum PFAS and hyperlipidemia.
Compared with the lowest quartile of perfluoromethylheptane sulfonic acid isomers (Sm-PFOS), the percentage change for hyperlipidemia was 57% and 41% in the third and highest quartile of PFOS. The positive association between Sm-PFOS and hyperlipidemia remained significant in population younger than 60 years, and the odds ratio for hyperlipidemia in fourth quartile of Sm-PFOS was 1.81.
These findings indicated that serum Sm-PFOS was independently associated with a higher risk for hyperlipidemia. The epidemiological study warrants further study to elucidate the causal relationship between them.
本研究旨在利用来自全国健康与营养调查的数据，探讨全氟烷基物质（PFAS）暴露与高血脂之间的关系。
共纳入 1600 名受试者，检测了 9 种 PFAS。采用多变量 logistic 回归分析探讨血清 PFAS 与高血脂的关系。
与全氟甲基庚烷磺酸异构体（Sm-PFOS）最低四分位相比，PFOS 第三和最高四分位的高血脂百分比变化分别为 57%和 41%。Sm-PFOS 与高血脂之间的正相关性在 60 岁以下人群中仍然显著，Sm-PFOS 第四四分位的高血脂比值比为 1.81。
这些发现表明血清 Sm-PFOS 与高血脂的风险增加独立相关。这项流行病学研究需要进一步研究以阐明它们之间的因果关系。
