Juel R
CRC Crit Rev Clin Lab Sci. 1979;10(2):113-46. doi: 10.3109/10408367909147131.
2,3-Diphosphoglycerate (2,3-DPG) was first discovered and isolated in 1925. However, it was not until 1967 that the function of 2,3-DPG was explained. This resulted in multiple research projects devoted to elucidating the mechanism by which 2,3-DPG exerts it effect on the oxygen affinity of hemoglobin. In addition, a vast amount of research has been devoted to assessing the role of 2,3-DPG in oxygen transport in various physiological and pathophysiological states. In many instances, the results of this research have produced conflicting data which have dampened the initial enthusiasm which followed the discovery of the function of 2,3-DPG. However, much of this conflicting data can be explained by the fact that 2,3-DPG is only one of a number of factors influencing the transport of oxygen to the tissues. Several of these factors influence oxygen transport independently as well as by altering the synthesis of 2,3-DPG and modifying its effect on hemoglobin. In spite of the conflicting results, the overall data gathered thus far appears to be sound enough to warrant the extensive research now being done, particularly in the area of blood storage and transfusion therapy.
2,3-二磷酸甘油酸（2,3-DPG）于1925年首次被发现并分离出来。然而，直到1967年2,3-DPG的功能才得到解释。这引发了多个研究项目，致力于阐明2,3-DPG对血红蛋白氧亲和力产生影响的机制。此外，大量研究致力于评估2,3-DPG在各种生理和病理生理状态下的氧运输中的作用。在许多情况下，这项研究的结果产生了相互矛盾的数据，这削弱了在发现2,3-DPG功能后最初的热情。然而，许多这种相互矛盾的数据可以用以下事实来解释：2,3-DPG只是影响氧气向组织运输的众多因素之一。其中一些因素独立地影响氧运输，以及通过改变2,3-DPG的合成并改变其对血红蛋白的作用来影响氧运输。尽管结果相互矛盾，但迄今为止收集到的总体数据似乎足够可靠，足以保证目前正在进行的广泛研究是合理的，特别是在血液储存和输血治疗领域。
