Sohmer P R, Dawson R B
CRC Crit Rev Clin Lab Sci. 1979 Nov;11(2):107-74. doi: 10.3109/10408367909105855.
This review will begin by giving the highlights of the history and explain development of the basic science knowledge of hemoglobin chemistry, function, and physiology. The necessary involvement of red cell metabolism, as it pertains to the maintenance of 2,3-diphosphoglycerate (2,3-DPG) levels, both normally and under the perturbed and experimental conditions of blood storage, will be given as part of the basic science data. The clinical science and transfusion data will comprise the main critical aspects of the paper. Analysis and comment of over 20 studies will be given on the effects of animal and human transfusions with altered 2,3-DPG levels. Decreased survival and organ function have been demonstrated with transfusion of low 2,3-DPG red cells, with or without anemia, in the conditions of exercise, shock, hypotension, ischemia, cardiac surgery, hypoxia, sepsis, and acidosis. By critical analysis of these studies, recommendations on general and specific patient needs for red cell transfusions with normal or high 2,3-DPG levels are given.
本综述将首先概述血红蛋白化学、功能和生理学的基础知识的历史与发展。作为基础科学数据的一部分，将阐述红细胞代谢在维持2,3-二磷酸甘油酸（2,3-DPG）水平方面的必要作用，包括正常情况以及血液储存的扰动和实验条件下的情况。临床科学和输血数据将构成本文的主要关键内容。将对20多项关于输注2,3-DPG水平改变的动物和人类输血效果的研究进行分析和评论。在运动、休克、低血压、缺血、心脏手术、缺氧、脓毒症和酸中毒等情况下，输注低2,3-DPG水平的红细胞（无论有无贫血）已证明会导致存活率降低和器官功能受损。通过对这些研究的批判性分析，针对一般和特定患者对正常或高2,3-DPG水平红细胞输血的需求给出了建议。
