Klarin Ivo
General Hospital Zadar, Department of Gastroenterology, Zadar, Croatia.
University of Zadar, Department for Health Studies, Zadar, Croatia.
Case Rep Gastrointest Med. 2023 Oct 10;2023:1057247. doi: 10.1155/2023/1057247. eCollection 2023.
Dermatofibrosarcoma protuberans (DFSP) is a low-to-intermediate grade sarcoma with a reported incidence of 4.1 per million person-years. Despite its local invasiveness, it rarely metastasizes (5% of cases). Fibrosarcomatous change in DFSP is a form of tumor progression that carries an increased risk of metastases. We reported a case of 45-year-old patient treated with adalimumab lasting 7 years for Crohn's disease who developed dermatofibrosarcoma protuberans with fibromatous changes. Adalimumab therapy was stopped before surgery, and ustekinumab was introduced 6 months after.
隆突性皮肤纤维肉瘤（DFSP）是一种低至中级别的肉瘤，报告发病率为每百万人年4.1例。尽管它具有局部侵袭性，但很少发生转移（5%的病例）。DFSP中的纤维肉瘤样改变是一种肿瘤进展形式，其转移风险增加。我们报告了一例45岁因克罗恩病接受阿达木单抗治疗7年的患者，该患者发生了伴有纤维瘤样改变的隆突性皮肤纤维肉瘤。阿达木单抗治疗在手术前停止，乌司奴单抗在6个月后开始使用。
