Mahato Abhishek, Jain Anurag, Manoj M G, Joshi Richa
Department of Nuclear Medicine, Command Hospital, Lucknow, Uttar Pradesh, India.
Department of Pathology, Command Hospital, Lucknow, Uttar Pradesh, India.
World J Nucl Med. 2023 Sep 6;22(3):244-247. doi: 10.1055/s-0043-1771280. eCollection 2023 Sep.
Urethral melanomas are a rare subtype of noncutaneous melanomas. The disease has a tendency to have skip lesions and early metastases as compared with cutaneous melanomas. The role of fluorine-18 fluorodeoxyglucose ( F-FDG) positron emission tomography computed tomography (PET-CT) is well established in cases of cutaneous melanomas and is recommended by the National Comprehensive Cancer Network (NCCN) for stage IIB to IV cancer. There are no established guidelines on the management of noncutaneous melanomas; however, a recently published United Kingdom national guideline aims to streamline the management of ano-uro-genital melanomas. The guideline describes a very limited role in the use of F-FDG PET-CT in this case scenario. The tendency to skip lesions, early metastases, involvement of brain parenchyma, and finally the usage of anti-PD-1 medications are key areas where F-FDG PET-CT has shown superiority over CT scan. With this case report, we aim to highlight the strength of F-FDG PET-CT in the management of urethral melanomas, which can be extrapolated to other ano-uro-genital melanomas.
尿道黑色素瘤是非皮肤黑色素瘤的一种罕见亚型。与皮肤黑色素瘤相比，该疾病倾向于出现跳跃性病变和早期转移。氟-18氟脱氧葡萄糖（¹⁸F-FDG）正电子发射断层扫描计算机断层扫描（PET-CT）在皮肤黑色素瘤病例中的作用已得到充分确立，美国国立综合癌症网络（NCCN）推荐其用于IIB期至IV期癌症。目前尚无关于非皮肤黑色素瘤管理的既定指南；然而，最近发布的英国国家指南旨在简化肛门泌尿生殖系统黑色素瘤的管理。该指南描述了¹⁸F-FDG PET-CT在这种情况下的作用非常有限。¹⁸F-FDG PET-CT在跳跃性病变、早期转移、脑实质受累以及抗PD-1药物的使用方面表现出优于CT扫描的优势，这些都是关键领域。通过本病例报告，我们旨在强调¹⁸F-FDG PET-CT在尿道黑色素瘤管理中的优势，这可以推广到其他肛门泌尿生殖系统黑色素瘤。
