Cukurova University Medical School, Department of Pathology, 01260, Saricam, Adana, Turkey.
Cukurova University Medical School, Department of Pathology, 01260, Saricam, Adana, Turkey.
Pathol Res Pract. 2020 Sep;216(9):153095. doi: 10.1016/j.prp.2020.153095. Epub 2020 Jun 29.
Primary melanoma of the urinary tract is a very rare and aggressive cancer. It accounts for less than 1% of all the melanoma cases, making it difficult to histopathologically diagnose and manage. We present a retrospective case series of eight primary urinary tract melanoma with clinical, pathological, and molecular findings to add more insight to this challenging disease. These cases were evaluated for histopathological, immunohistochemical, and molecular features of melanoma that were most commonly found in the urethra, followed by those in the bladder and ureter. Identification of nested growth patterns and in situ melanocytic components at cell edges are helpful in the histopathological diagnosis of amelanotic or hypomelanotic tumors. Our results indicate that urinary tract melanoma has several molecular traits, such as gene expression patterns. Genetic mutations may be related to metastasis, as well as provide targets for the management programs.
原发性尿路黑色素瘤是一种非常罕见且侵袭性强的癌症。它占所有黑色素瘤病例的比例不到 1%，因此在组织病理学诊断和管理方面具有挑战性。我们报告了 8 例原发性尿路黑色素瘤的回顾性病例系列，以增加对这种具有挑战性疾病的了解。这些病例评估了黑色素瘤的组织病理学、免疫组织化学和分子特征，这些特征最常见于尿道，其次是膀胱和输尿管。在组织病理学诊断无色素或低色素肿瘤时，识别巢状生长模式和细胞边缘的原位黑素细胞成分很有帮助。我们的结果表明，尿路黑色素瘤具有多种分子特征，例如基因表达模式。遗传突变可能与转移有关，并为管理方案提供靶点。
