Bawa Fathima N Cassim, Zhang Yanqiao
Department of Integrative Medical Sciences, Northeast Ohio Medical University, Rootstown, OH, USA 44272.
Liver Res. 2023 Sep;7(3):189-195. doi: 10.1016/j.livres.2023.07.002. Epub 2023 Jul 16.
Retinoic acid (RA) is a metabolite of vitamin A and is essential for development and growth as well as cellular metabolism. Through genomic and nongenomic actions, RA regulates a variety of physiological functions. Dysregulation of RA signaling is associated with many diseases. Targeting RA signaling has been proven valuable to human health. All-trans retinoic acid (AtRA) and anthracycline-based chemotherapy are the standard treatment of acute promyelocytic leukemia (APL). Both human and animal studies have shown a significant relationship between RA signaling and the development and progression of nonalcoholic fatty liver disease (NAFLD). In this review article, we will first summarize vitamin A metabolism and then focus on the role of RA signaling in NAFLD. AtRA inhibits the development and progression of NAFLD via regulating lipid metabolism, inflammation, thermogenesis, etc.
视黄酸（RA）是维生素A的一种代谢产物，对发育、生长以及细胞代谢至关重要。通过基因组和非基因组作用，RA调节多种生理功能。RA信号传导失调与许多疾病相关。靶向RA信号传导已被证明对人类健康有价值。全反式视黄酸（AtRA）和基于蒽环类药物的化疗是急性早幼粒细胞白血病（APL）的标准治疗方法。人和动物研究均表明RA信号传导与非酒精性脂肪性肝病（NAFLD）的发生和发展之间存在显著关系。在这篇综述文章中，我们将首先总结维生素A代谢，然后重点关注RA信号传导在NAFLD中的作用。AtRA通过调节脂质代谢、炎症、产热等抑制NAFLD的发生和发展。
