Döhring S, Schulitz K P, Lenz G
Neurochirurgia (Stuttg). 1986 Sep;29 Suppl 1:146-8. doi: 10.1055/s-2008-1054099.
Myeloscopic normal findings are demonstrated in the rhesus monkey (macaca fascicularis, crab-eating monkey). It can also be shown that six weeks after intrathecal administration of the proteolytic enzyme chymopapain, obvious pathological changes can be seen endoscopically in the nerve roots. It can, therefore, be said that the intrathecal administration of chymopapain is strictly contraindicated due to the proven unfavourable neurotoxic side effects.
在恒河猴（食蟹猴，猕猴属）中显示出脊髓镜检查的正常结果。还可以表明，在鞘内注射蛋白水解酶木瓜凝乳蛋白酶六周后，在内窥镜下可在神经根中看到明显的病理变化。因此，可以说，由于已证实的不利神经毒性副作用，鞘内注射木瓜凝乳蛋白酶是严格禁忌的。
