Nguyen C M, Haughton V M, Ho K C
Department of Radiology, Medical College of Wisconsin, Froedtert Memorial Lutheran Hospital, Milwaukee 53226.
Radiology. 1990 Feb;174(2):417-9. doi: 10.1148/radiology.174.2.2296652.
Because arachnoiditis occurred in a previous experimental study, the authors performed additional experimental injections of chymopapain in the epidural space. Four monkeys received epidural injections of 100 units of chymopapain in 1.2 mL of saline on days 1, 8, and 16 of the experiment; four control animals received injections of 1.2 mL of 0.9% saline on the same days. Both groups were killed on the 84th day. The dural sac was removed, fixed, sectioned, stained, and examined microscopically. No significant changes were found in the arachnoid, dura, or epidural space of the treated animals. Chymopapain, even if injected repeatedly into the epidural space, does not cause significant scarring in the meninges.
由于在之前的一项实验研究中出现了蛛网膜炎，作者在硬膜外间隙进行了额外的木瓜凝乳蛋白酶实验性注射。在实验的第1天、第8天和第16天，四只猴子接受了在1.2毫升盐水中注射100单位木瓜凝乳蛋白酶的硬膜外注射；四只对照动物在相同日期接受了1.2毫升0.9%盐水的注射。两组动物均在第84天处死。取出硬脊膜囊，固定、切片、染色并进行显微镜检查。在接受治疗的动物的蛛网膜、硬脑膜或硬膜外间隙未发现明显变化。即使将木瓜凝乳蛋白酶反复注射到硬膜外间隙，也不会在脑膜中引起明显的瘢痕形成。
