Department of Animal Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran.
Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Curr Rheumatol Rev. 2024;20(2):182-190. doi: 10.2174/0115733971251184230921042511.
Rheumatoid arthritis (RA), an autoimmune joint inflammatory disease, presents a significant challenge due to its prevalence, particularly among women, affecting around 6% of individuals over the age of 65. Novel insights into disease mechanisms are crucial for improved diagnostic and therapeutic approaches.
Long non-coding RNAs (lncRNAs) have emerged as potential contributors to the pathogenesis of various autoimmune diseases, including RA. This study aims to investigate the unique roles of four lncRNAs-NEAT1, GAS5, TMEVPG1, and GAPLINC-in the etiology of RA.
Leveraging isolated serum samples from RA patients and healthy controls, we comprehensively evaluated the expression profiles of these lncRNAs.
Notably, our findings unveil a distinctive landscape of lncRNA expressions in RA. Among them, GAPLINC exhibited a significantly elevated average expression in the serum samples of RA patients, suggesting a potential biomarker candidate for disease stratification. Importantly, reduced expression of NEAT1 and GAS5 was observed in RA patients, highlighting their possible roles as diagnostic and prognostic markers. Conversely, TMEVPG1 displayed unaltered expression levels in RA samples.
Our study introduces a novel dimension to RA research by identifying NEAT1, GAS5, and GAPLINC as promising serological biomarkers. These findings hold significant clinical implications, offering potential avenues for improved diagnosis, disease monitoring, and therapeutic interventions in RA.
类风湿关节炎（RA）是一种自身免疫性关节炎症性疾病，由于其高发率，尤其是在女性中的高发率，给患者带来了很大的挑战，大约 65 岁以上的人群中有 6%受到影响。对疾病机制的新认识对于改进诊断和治疗方法至关重要。
长链非编码 RNA（lncRNA）已成为各种自身免疫性疾病（包括 RA）发病机制的潜在贡献者。本研究旨在探讨四种 lncRNA-NEAT1、GAS5、TMEVPG1 和 GAPLINC 在 RA 发病机制中的独特作用。
利用从 RA 患者和健康对照者分离的血清样本，我们全面评估了这些 lncRNA 的表达谱。
值得注意的是，我们的研究结果揭示了 RA 中 lncRNA 表达的独特模式。其中，GAPLINC 在 RA 患者的血清样本中表现出明显升高的平均表达，表明其可能是疾病分层的生物标志物候选物。重要的是，我们观察到 RA 患者中 NEAT1 和 GAS5 的表达减少，提示其可能作为诊断和预后标志物。相反，TMEVPG1 在 RA 样本中的表达水平没有改变。
我们的研究通过鉴定 NEAT1、GAS5 和 GAPLINC 作为有前途的血清学生物标志物，为 RA 研究提供了新的视角。这些发现具有重要的临床意义，为 RA 的改进诊断、疾病监测和治疗干预提供了潜在途径。
