Moroji T, Hagino Y
Neuropeptides. 1986 Oct;8(3):273-86. doi: 10.1016/0143-4179(86)90054-5.
The effects of CCK-8, ceruletide, their non-sulfated forms and CCK-4 on locomotor activity and rearing in mice were examined. CCK-8 and ceruletide, but not their non-sulfated forms and CCK-4, significantly inhibited the behavioral parameters dose-dependently. The inhibitory effects of CCK-8 and ceruletide were similar, but ceruletide acted more slowly and its inhibitory effect continued much longer than CCK-8, suggesting a difference in stability with the chemical structure. The antagonistic effects of ceruletide on behavioral changes induced by DA agonists were also examined. Peripherally injected ceruletide antagonized both methylphenidate- and methamphetamine-induced hyperactivity in mice dose-dependently, whereas it had no dose-related antagonistic effect on methylphenidate-induced stereotyped behavior. Ceruletide also significantly inhibited apomorphine-induced hyperactivity when injected peripherally. However, no obvious dose-response relationship was observed in either intensity or duration of inhibitory action of ceruletide. These findings suggest that ceruletide does not interfere with dopaminergic transmission due to the blockade of postsynaptic DA receptors in the brain. In conclusion, peripheral injection of CCK-8 and ceruletide may affect directly or indirectly dopamine function producing behavioral changes that resemble those of neuroleptics in some respects.
研究了CCK-8、雨蛙肽、它们的非硫酸化形式以及CCK-4对小鼠运动活性和竖毛行为的影响。CCK-8和雨蛙肽，而非它们的非硫酸化形式和CCK-4，能剂量依赖性地显著抑制行为参数。CCK-8和雨蛙肽的抑制作用相似，但雨蛙肽起效更慢，其抑制作用持续时间比CCK-8长得多，这表明其化学结构在稳定性上存在差异。还研究了雨蛙肽对多巴胺激动剂诱导的行为变化的拮抗作用。外周注射雨蛙肽能剂量依赖性地拮抗小鼠中哌醋甲酯和甲基苯丙胺诱导的多动，而对哌醋甲酯诱导的刻板行为没有剂量相关的拮抗作用。外周注射雨蛙肽也能显著抑制阿扑吗啡诱导的多动。然而，雨蛙肽抑制作用的强度或持续时间均未观察到明显的剂量反应关系。这些发现表明，雨蛙肽不会因阻断脑中的突触后多巴胺受体而干扰多巴胺能传递。总之，外周注射CCK-8和雨蛙肽可能直接或间接影响多巴胺功能，产生在某些方面类似于抗精神病药物的行为变化。
