Zetler G
Eur J Pharmacol. 1983 Aug 19;92(1-2):151-4. doi: 10.1016/0014-2999(83)90123-1.
The antinociceptive effects of ceruletide (CER, 0.03 mg/kg s.c.), cholecystokinin octapeptide (CCK-8, 0.12 mg/kg s.c.) and morphine (0.33 mg/kg s.c.) were determined in mice with the hot plate test using paw licking and jumping up as endpoints. Licking was more resistant to antinociceptive effects than was jumping. Apomorphine 0.25 mg/kg, per se, produced more antinociception with licking than with jumping. With the jumping reaction, but not the licking response, apomorphine 0.063 and 0.125 mg/kg abolished the effect of morphine but did not modify that of CER and CCK-8.
采用热板试验，以舔足和跳跃作为观察指标，测定蛙皮素（CER，0.03mg/kg皮下注射）、八肽胆囊收缩素（CCK-8，0.12mg/kg皮下注射）和吗啡（0.33mg/kg皮下注射）对小鼠的镇痛作用。与跳跃相比，舔足对镇痛作用的耐受性更强。单独使用0.25mg/kg阿扑吗啡时，对舔足的镇痛作用比对跳跃的更强。对于跳跃反应而非舔足反应，0.063mg/kg和0.125mg/kg阿扑吗啡可消除吗啡的作用，但不影响CER和CCK-8的作用。
