Sarter M
Neuropsychobiology. 1986;15(3-4):192-200. doi: 10.1159/000118263.
Four possible types of nootropic drugs are classified theoretically according to their possible effects on cognitive functions. Among the factors usually varied in psychopharmacological designs, the significance of the time of application of the drug is stressed. Considering the relations between the time of application of nootropic drugs within standardized experimental plans and their effects on cognitive processes, ideal time of application-response curves for each of these types of nootropic compounds are proposed. These curves may represent experimental tools in investigating the mode of action of nootropic drugs. Finally, some experimental results are presented which are relevant to this approach. Overall, however, the rationale of these theoretical considerations remains largely unproven because of the lack of studies to date designed to evaluate the mechanisms of drug action by varying the time of application of a nootropic compound.
根据对认知功能可能产生的影响，理论上对四种可能类型的益智药进行了分类。在心理药理学设计中通常变化的因素中，强调了药物给药时间的重要性。考虑到在标准化实验方案中益智药的给药时间与其对认知过程的影响之间的关系，提出了每种类型的益智化合物的理想给药时间-反应曲线。这些曲线可能代表研究益智药作用方式的实验工具。最后，给出了一些与该方法相关的实验结果。然而，总体而言，由于迄今为止缺乏旨在通过改变益智化合物的给药时间来评估药物作用机制的研究，这些理论考量的基本原理在很大程度上仍未得到证实。
