Neurology Clinic, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey.
Neurology Clinic, Etlik City Hospital, Ankara, Turkey.
Neurol Res. 2024 Mar;46(3):207-212. doi: 10.1080/01616412.2023.2265250. Epub 2024 Jan 22.
In this research, paying particular attention to freezıng of gait (FOG), we aimed to investigate the associations between the clinical features and quality of lilfe (QOL) indexes comparatively in our PD subjects with and without STN-DBS therapy.
All consecutive PD subjects with and without STN-DBS who applied to our movement disorders outpatient clinics between January/2022 and September/2022; and accepted to participate in the study were enrolled. The demographic data and clinical features were noted. Besides, the MDS-UPDRS, the FOG Questionnaire (FOGQ) and the Parkinson's Disease Questionnaire (PDQ-39) have also been performed on all individuals.
Overall, 105 patients with PD participated in this study (34 patients with STN-DBS, 71 patients without STN-DBS). No difference was found in the PDQ-39 scores between patients with and without STN-DBS. The correlation analyses between the PQQ-39 scores and the clinical parameters revealed significant moderate correlations with the FOGQ score and low correlations with MDS-UPDRS scores. The analyses repeated in either patient group showed that there were no correlations between the MDS-UPDRS scores and PDQ-39 indexes in the DBS group. Besides, the correlations between the PDQ-39 scores and the FOG scores were more prominent in patients without DBS therapy.
FOG was found to be associated with worse QOL status in both patients with and without STN-DBS therapy. However, the correlations analyses in either group showed that FOG was a more significant determinant in the QOL indexes in patients without DBS. Future studies evaluating the impact of other clinical features such as falls and gait impairment in QOL of patients with STN-DBS may provide contributions to the current evidence.
在这项研究中，我们特别关注冻结步态（FOG），旨在比较我们的 PD 患者中接受和未接受 STN-DBS 治疗的患者，比较其临床特征和生活质量（QOL）指标之间的相关性。
所有连续的 PD 患者，他们在 2022 年 1 月至 2022 年 9 月之间向我们的运动障碍门诊就诊，并接受了参与研究的邀请；记录了他们的人口统计学数据和临床特征。此外，还对所有个体进行了 MDS-UPDRS、FOG 问卷（FOGQ）和帕金森病问卷（PDQ-39）的评估。
总体而言，105 名 PD 患者参与了这项研究（34 名接受了 STN-DBS 治疗，71 名未接受 STN-DBS 治疗）。接受和未接受 STN-DBS 治疗的患者的 PDQ-39 评分没有差异。PQQ-39 评分与临床参数之间的相关性分析显示，与 FOGQ 评分呈显著中度相关，与 MDS-UPDRS 评分呈低度相关。在重复分析任何一组患者时发现，DBS 组中 MDS-UPDRS 评分与 PDQ-39 指标之间没有相关性。此外，在未接受 DBS 治疗的患者中，PDQ-39 评分与 FOG 评分之间的相关性更为显著。
在接受和未接受 STN-DBS 治疗的患者中，FOG 与 QOL 状况较差相关。然而，在两组的相关性分析中发现，在未接受 DBS 治疗的患者中，FOG 是 QOL 指标的更重要决定因素。未来评估其他临床特征（如跌倒和步态障碍）对接受 STN-DBS 治疗的患者 QOL 的影响的研究可能会对现有证据做出贡献。
