Onder Halil, Comoglu Selcuk
Neurology Clinic, Etlik City Hospital, Varlık, Halil Sezai Erkut Street. No:5, 06170 Yenimahalle, 06110, Ankara, Turkey.
J Neural Transm (Vienna). 2024 Aug;131(8):931-940. doi: 10.1007/s00702-024-02778-y. Epub 2024 Apr 30.
The impact of STN-DBS on NMS remains rather as an underestimated topic. Besides, the significance of NMSs in QOL indexes of PD subjects with STN-DBS is unknown. We primarily aimed to evaluate the NMSs and their significance in QOL indexes in PD subjects comparatively with and without STN-DBS therapy. We enrolled all consecutive PD subjects with and without STN-DBS who applied to our movement disorders outpatient clinics between January/2023 and September/2023. We performed comprehensive assessments of the motor and nonmotor features including the clinical scales of Movement Disorder Society-sponsored revision of the MDS-UPDRS, NMSS, HAM-A, HAM-D, and the PDQ-39. Overall, 48 PD subjects with STN-DBS and 161 without STN-DBS treatment were included. The comparative analyses revealed that the sub-scores of the MDS-UPDRS-2, -3 and -4 were higher in the STN-DBS group. However, the MDS-UDPRS-1 and the total scores of the NMSS were similar between groups. Among eight subitems of the NMSS, only, the sub scores of the mood/cognition and the gastrointestinal tract differed. Remarkably, the significant correlations between the scores of the QOL and the NMSS scores in the STN-DBS (-) group, did not persist within the STN-DBS group. Remarkably, the correlations between the NMSS and PQQ-39 disappeared for most of the sub scores within the STN-DBS group. We found indirect evidence regarding the benefit of STN-DBS therapy on NMSs in our cross-sectional study. Besides, we found weaker impact of NMSs in QOL indexes in PD subjects with STN-DBS therapy.
丘脑底核深部脑刺激（STN-DBS）对非运动症状（NMS）的影响仍是一个被低估的话题。此外，NMS在接受STN-DBS治疗的帕金森病（PD）患者生活质量（QOL）指标中的意义尚不清楚。我们的主要目的是比较接受和未接受STN-DBS治疗的PD患者的NMS及其在QOL指标中的意义。我们纳入了2023年1月至2023年9月期间连续申请到我们运动障碍门诊的所有接受和未接受STN-DBS治疗的PD患者。我们对运动和非运动特征进行了全面评估，包括运动障碍协会赞助修订的MDS-UPDRS、NMSS、HAM-A、HAM-D和PDQ-39的临床量表。总体而言，纳入了48例接受STN-DBS治疗的PD患者和161例未接受STN-DBS治疗的患者。比较分析显示，STN-DBS组的MDS-UPDRS-2、-3和-4的子分数较高。然而，两组之间的MDS-UDPRS-1和NMSS总分相似。在NMSS的八个子项目中，只有情绪/认知和胃肠道的子分数不同。值得注意的是，STN-DBS（-）组中QOL分数与NMSS分数之间的显著相关性在STN-DBS组中并未持续存在。值得注意的是，在STN-DBS组中，大多数子分数的NMSS与PQQ-39之间的相关性消失。在我们的横断面研究中，我们发现了关于STN-DBS治疗对NMS有益的间接证据。此外，我们发现NMS对接受STN-DBS治疗的PD患者QOL指标的影响较弱。
