非上皮性卵巢癌的临床病理特征和生存趋势：监测、流行病学和最终结果（SEER）数据库分析。

Clinicopathological Features and Survival Trends of Non-Epithelial Ovarian Cancer: Analysis of the Surveillance, Epidemiology, and End Results (SEER) Database.

机构信息

Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China,

Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

出版信息

Oncol Res Treat. 2023;46(11):476-492. doi: 10.1159/000534674. Epub 2023 Oct 19.

DOI:10.1159/000534674

PMID:37857263

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10623401/

Abstract

INTRODUCTION

Owing to their low incidence, no reliable statistics about prognostication derived from large sample sizes have been reported of malignant ovarian germ cell tumors (MOGCTs) and sex cord-stromal tumors (SCSTs). The present study aimed to investigate the clinicopathological prognostic factors and the survival trends of MOGCTs and SCSTs.

MATERIALS AND METHODS

Patients with MOGCTs and SCSTs were recorded in the Surveillance, Epidemiology, and End Results (SEER) database diagnosed between 2000 and 2019. Clinical, demographic, and treatment characteristics were compared between groups of MOGCTs and SCSTs. Cox risk regression analysis and Kaplan-Meier survival curves were used to compare overall survival (OS) and cancer-specific survival (CSS) and to assess the prognostic factors.

RESULTS

Information about 2,506 patients with MOGCTs and 1,556 patients with SCSTs was extracted from the SEER database, respectively. Aged <40 years and single were more common in patients with MOGCTs than in those with SCSTs. The vast majority of patients with MOGCTs and SCSTs underwent surgery (98.1% vs. 94.5%; p < 0.001), and women with MOGCTs were more likely to receive chemotherapy than women with SCSTs (56.1% vs. 32.2%; p < 0.001). For both patients before and after propensity-score matching, the 5-year OS rates of patients with SCSTs were lower than those of patients with MOGCTs (p < 0.05). In multivariate Cox regression analysis, both age and surgery were independent predictors of OS in patients with MOGCTs and SCSTs. FIGO staging was an independent predictor of CSS in MOGCT patients. Tumor size and chemotherapy were also independent predictors of CSS in patients with SCSTs.

CONCLUSION

Compared to patients with SCSTs, those with MOGCTs tended to be younger and had a higher OS and CSS. Adjuvant chemotherapy after surgery did not prolong OS and CSS in patients with SCSTs.

摘要

简介

由于发病率低，目前尚无大样本量恶性卵巢生殖细胞肿瘤（MOGCT）和性索-间质肿瘤（SCST）的可靠预后统计数据。本研究旨在探讨 MOGCT 和 SCST 的临床病理预后因素和生存趋势。

材料与方法

从 2000 年至 2019 年诊断的监测、流行病学和最终结果（SEER）数据库中记录了 MOGCT 和 SCST 患者的信息。比较了 MOGCT 和 SCST 组之间的临床、人口统计学和治疗特征。Cox 风险回归分析和 Kaplan-Meier 生存曲线用于比较总生存率（OS）和癌症特异性生存率（CSS），并评估预后因素。

结果

从 SEER 数据库中分别提取了 2506 例 MOGCT 和 1556 例 SCST 患者的信息。MOGCT 患者中年龄<40 岁和单身的比例高于 SCST 患者。绝大多数 MOGCT 和 SCST 患者均接受了手术（98.1% vs. 94.5%；p < 0.001），且 MOGCT 患者比 SCST 患者更有可能接受化疗（56.1% vs. 32.2%；p < 0.001）。在倾向评分匹配前后，SCST 患者的 5 年 OS 率均低于 MOGCT 患者（p < 0.05）。多变量 Cox 回归分析显示，年龄和手术均是 MOGCT 和 SCST 患者 OS 的独立预测因素。FIGO 分期是 MOGCT 患者 CSS 的独立预测因素。肿瘤大小和化疗也是 SCST 患者 CSS 的独立预测因素。