Department of Ultrasonography, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, No.9, Jinsui Road, Guangzhou, Guangdong, China.
The Sixth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen, Guangdong, China.
BMC Nephrol. 2023 Oct 19;24(1):306. doi: 10.1186/s12882-023-03357-1.
To study the value of shear wave elasticity and shear wave dispersion imaging to evaluate the viscoelasticity of renal parenchyma in children with glomerular diseases.
Forty-three children with glomerular diseases were prospectively evaluated by shear wave elasticity (SWE) and shear wave dispersion imaging (SWD); 43 healthy volunteers served as the control group. The shear wave velocities (SWV) and the dispersion slopes were measured at the upper, middle, and lower poles of both kidneys. The analysis of mean SWV and mean dispersion slope in control and patient groups was used to further evaluate the value of SWE and SWD in the viscoelasticity of renal parenchyma in children with glomerular disease.
The mean SWV in children with glomerular disease was higher than that in the healthy control group (1.61 ± 0.09 m/s vs. 1.43 ± 0.07 m/s, p < 0.001). Compared with healthy group, the mean dispersion slope in children with glomerular disease was significantly increased (13.5 ± 1.39 (m/s)/kHz vs. 12.4 ± 1.40 (m/s)/kHz, p < 0.001). Correlation analysis showed absence of correlation between the SWV and dispersion slope of occult blood, serum creatinine, 24-h urine protein, blood albumin, BMI and ROI box depth of children with glomerular disease.
The present study shows that it is feasible to use SWE and SWD to evaluate the difference of viscoelasticity of the renal parenchyma between healthy children and those with glomerular disease.
研究剪切波弹性和剪切波弥散成像评估肾小球疾病患儿肾实质粘弹性的价值。
前瞻性评估 43 例肾小球疾病患儿剪切波弹性（SWE）和剪切波弥散成像（SWD）；43 名健康志愿者作为对照组。测量双侧肾脏上极、中极和下极的剪切波速度（SWV）和弥散斜率。分析对照组和患者组的平均 SWV 和平均弥散斜率，进一步评估 SWE 和 SWD 在肾小球疾病患儿肾实质粘弹性中的价值。
肾小球疾病患儿的平均 SWV 高于健康对照组（1.61±0.09 m/s 比 1.43±0.07 m/s，p<0.001）。与健康组相比，肾小球疾病患儿的平均弥散斜率明显升高（13.5±1.39（m/s）/kHz 比 12.4±1.40（m/s）/kHz，p<0.001）。相关性分析显示，肾小球疾病患儿的 SWV 与潜血、血清肌酐、24 小时尿蛋白、血白蛋白、BMI 和 ROI 框深度之间无相关性。
本研究表明，SWE 和 SWD 可用于评估健康儿童和肾小球疾病患儿肾实质粘弹性的差异。
