融合脂质对线粒体动力学的控制。
Control of mitochondrial dynamics by a fusogenic lipid.
机构信息
Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
出版信息
Trends Cell Biol. 2023 Dec;33(12):1005-1006. doi: 10.1016/j.tcb.2023.10.006. Epub 2023 Oct 17.
Abstract
Mitochondrial fusion enables cooperation between the mitochondrial population and is critical for mitochondrial function. Phosphatidic acid (PA) on the mitochondrial surface has a key role in mitochondrial fusion. A recent study by Su et al. shows that the nucleoside diphosphate (NDP) kinase NME3 recognizes PA and mediates its effects on mitochondrial dynamics.
摘要
线粒体融合使线粒体群体能够相互合作，对于线粒体功能至关重要。线粒体表面的磷酸酸（PA）在线粒体融合中起着关键作用。苏等人的最近一项研究表明，核苷二磷酸激酶 NME3 识别 PA 并介导其对线粒体动态的影响。
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本文引用的文献
1
NME3 binds to phosphatidic acid and mediates PLD6-induced mitochondrial tethering.NME3 与磷脂酸结合并介导 PLD6 诱导的线粒体连接。
J Cell Biol. 2023 Oct 2;222(10). doi: 10.1083/jcb.202301091. Epub 2023 Aug 16.
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Fission and fusion machineries converge at ER contact sites to regulate mitochondrial morphology.裂变和融合机制在 ER 接触位点汇聚，以调节线粒体形态。
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Mitochondrial Dynamics and Its Involvement in Disease.线粒体动态及其与疾病的关系。
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Two separate functions of NME3 critical for cell survival underlie a neurodegenerative disorder.NME3 的两种独立功能对神经退行性疾病中的细胞存活至关重要。
Proc Natl Acad Sci U S A. 2019 Jan 8;116(2):566-574. doi: 10.1073/pnas.1818629116. Epub 2018 Dec 26.
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Membrane trafficking. Nucleoside diphosphate kinases fuel dynamin superfamily proteins with GTP for membrane remodeling.膜运输。核苷二磷酸激酶为动力蛋白超家族蛋白提供 GTP 燃料，以进行膜重塑。
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SLP-2 is required for stress-induced mitochondrial hyperfusion.应激诱导的线粒体过度融合需要SLP-2。
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A common lipid links Mfn-mediated mitochondrial fusion and SNARE-regulated exocytosis.一种常见脂质将线粒体融合蛋白介导的线粒体融合与SNARE调节的胞吐作用联系起来。
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