Department of Psychology, Colorado State University, Fort Collins, CO, USA.
University of Tartu, Tartu, Estonia; Montreal Neurological Institute, McGill University, Montreal, QC, Canada.
J Affect Disord. 2024 Jan 1;344:619-627. doi: 10.1016/j.jad.2023.10.068. Epub 2023 Oct 18.
Depression has frequently been associated with smaller hippocampal volume. The hippocampus varies in function along its anterior-posterior axis, with the anterior hippocampus more strongly associated with stress and emotion processing. The goals of this study were to examine the associations among parental history of anxiety/depression, polygenic risk scores for depression (PGS-DEP), and anterior and posterior hippocampal volumes in children and adolescents. To examine specificity to PGS-DEP, we examined associations of educational attainment polygenic scores (PGS-EA) with anterior and posterior hippocampal volume.
Participants were 350 3- to 21-year-olds (46 % female). PGS-DEP and PGS-EA were computed based on recent, large-scale genome-wide association studies. High-resolution, T1-weighted magnetic resonance imaging (MRI) data were acquired, and a semi-automated approach was used to segment the hippocampus into anterior and posterior subregions.
Children and adolescents with higher polygenic risk for depression were more likely to have a parent with a history of anxiety/depression. Higher polygenic risk for depression was significantly associated with smaller anterior but not posterior hippocampal volume. PGS-EA was not associated with anterior or posterior hippocampal volumes.
Participants in these analyses were all of European ancestry.
Polygenic risk for depression may lead to smaller anterior but not posterior hippocampal volume in children and adolescents, and there may be specificity of these effects to PGS-DEP rather than PGS-EA. These findings may inform the earlier identification of those in need of support and the design of more effective, personalized treatment strategies.
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抑郁与海马体体积较小经常相关。海马体在其前后轴上的功能不同，前部海马体与应激和情绪处理的关系更为密切。本研究的目的是探讨儿童和青少年中父母焦虑/抑郁史、抑郁多基因风险评分（PGS-DEP）以及前、后海马体体积之间的关系。为了检验 PGS-DEP 的特异性，我们还检验了教育程度多基因评分（PGS-EA）与前、后海马体体积的相关性。
参与者为 350 名 3 至 21 岁的儿童和青少年（46%为女性）。PGS-DEP 和 PGS-EA 是根据最近的大规模全基因组关联研究计算得出的。采集高分辨率 T1 加权磁共振成像（MRI）数据，并采用半自动方法将海马体分为前、后亚区。
具有较高抑郁多基因风险的儿童和青少年更有可能有一位有焦虑/抑郁病史的父母。较高的抑郁多基因风险与前海马体体积较小显著相关，但与后海马体体积无关。PGS-EA 与前、后海马体体积均无相关性。
这些分析的参与者均为欧洲血统。
抑郁的多基因风险可能导致儿童和青少年前海马体体积较小，但不会导致后海马体体积较小，并且这些影响可能具有 PGS-DEP 而非 PGS-EA 的特异性。这些发现可能有助于更早地识别需要支持的人群，并设计更有效、个性化的治疗策略。
