Department of Gastroenterology, Dietetics and Internal Diseases, Poznan University of Medical Sciences, Przybyszewskiego 49, 60-355 Poznan, Poland; Doctoral School, Poznan University of Medical Sciences, Bukowska 70, 60-812 Poznan, Poland.
Institute of Human Genetics, Polish Academy of Sciences, 60-479 Poznan, Poland.
Gene. 2024 Jan 30;893:147909. doi: 10.1016/j.gene.2023.147909. Epub 2023 Oct 18.
Several studies showed the correlation of retinol-binding protein 4 (RBP4) with increased cardiovascular risk - including higher values of carotid intima-media thickness (cIMT) - particularly in individuals with obesity.
Our study aimed to investigate the impact of rs10882273; rs3758538; rs3758539, and rs7094671 RBP4 gene variants on RBP4 serum concentrations as well as cIMT values (a marker of subclinical atherosclerosis) among female patients with obesity.
We recruited 74 women with obesity and 24 women without obesity as a study and control group, respectively. The genotypic and allelic frequencies of RBP4 gene variants were evaluated for associations with serum RBP4 and cIMT.
The median serum RBP4 concentrations were 20.30 µg/mL and 19.80 µg/mL in the patients and control group, respectively (p = 0.740). No significant differences were seen in cIMT values between the two studied groups (0.60 [0.50-1.00] vs. 0.60 ± 0.10 in the patient and control group, respectively); however, the results were close to reaching significance (p = 0.071), similar as in observed association of the minor haplotype AA for rs7084671 and rs375839 with female obesity (p = 0.0559). The correlation analysis showed no significant differences between RBP4 gene variants with serum RBP4 and cIMT.
According to our knowledge, this is the first study investigating the association between RBP4 gene variants and serum RBP4 and cIMT among Polish female patients with obesity. However, our results show that genetic variants rs10882273, rs3758538, rs3758539, and rs7094671 of the RBP4 gene are not associated with RBP4 serum concentrations or cIMT values among women with obesity.
多项研究表明视黄醇结合蛋白 4（RBP4）与心血管风险增加相关，包括颈动脉内膜中层厚度（cIMT）增加，尤其是在肥胖个体中。
本研究旨在探讨 RBP4 基因 rs10882273、rs3758538、rs3758539 和 rs7094671 变异对肥胖女性患者 RBP4 血清浓度和 cIMT 值（亚临床动脉粥样硬化的标志物）的影响。
我们招募了 74 名肥胖女性患者和 24 名非肥胖女性作为研究组和对照组。评估 RBP4 基因变异的基因型和等位基因频率与血清 RBP4 和 cIMT 的相关性。
患者组和对照组的血清 RBP4 浓度中位数分别为 20.30μg/mL 和 19.80μg/mL（p=0.740）。两组间 cIMT 值无显著差异（患者组为 0.60[0.50-1.00]，对照组为 0.60±0.10），但结果接近显著性水平（p=0.071），与 rs7084671 和 rs375839 的较小等位基因 AA 与女性肥胖的关联结果相似（p=0.0559）。相关性分析显示，RBP4 基因变异与血清 RBP4 和 cIMT 之间无显著差异。
据我们所知，这是第一项研究 RBP4 基因变异与波兰肥胖女性患者血清 RBP4 和 cIMT 之间关系的研究。然而，我们的结果表明，RBP4 基因的 rs10882273、rs3758538、rs3758539 和 rs7094671 等遗传变异与肥胖女性的 RBP4 血清浓度或 cIMT 值无关。
