Kim Minjae, Lee Yeon Jung, Hwang Jaeuk, Woo Sung-Il, Hahn Sang-Woo
Department of Psychiatry, Soonchunhyang University Seoul Hospital, Soonchunhyang University College of Medicine, Seoul, Korea.
Clin Psychopharmacol Neurosci. 2023 Nov 30;21(4):787-797. doi: 10.9758/cpn.23.1064. Epub 2023 Jun 22.
: Suicidal ideation is one of the strongest predictors of suicide, and its relevance to impulsivity in depressed patients has been accumulated. Furthermore, high impulsivity patients show the attenuation of the Nogo amplitude in the GoNogo event-related potential (ERP). The purpose of the current study is to determine the correlation of Nogo ERP to the suicidal ideation depending on the condition of its presence or absence in major depressive disorder (MDD) patients.
: A total 162 participants (104 patients with suicidal ideation, 31 patients without suicidal ideation, and 27 healthy controls) were recruited, and performed GoNogo tasks during the electroencephalogram measurement. Depression, anxiety, suicidal ideation and impulsivity were assessed by self-rating scales. The clinical measures, behavioral data and Nogo ERP were compared among groups.
: The MDD with suicidal ideation (SI) group showed significantly decreased Nogo P3 amplitudes compared to MDD without SI (Fz and Cz electrodes) and control group (all electrodes). The MDD with SI group also had significantly low accuracy of both Go and Nogo trails, compared to the MDD without group. The Nogo P3 amplitudes showed the negative relation to the scores of impulsivity, depression, anxiety and SI.
: Our results concluded that the Nogo P3 ERP amplitude was decreased in MDD patients with SI compared to MDD patients without SI and controls. These findings suggest that the decreased Nogo P3 amplitude is the one of the candidate biomarker for impulsivity in MDD patients to evaluating SI.
自杀意念是自杀最强的预测因素之一，其与抑郁症患者冲动性的相关性已有积累。此外，高冲动性患者在GoNogo事件相关电位（ERP）中Nogo波幅会减弱。本研究的目的是根据重度抑郁症（MDD）患者有无自杀意念的情况，确定Nogo ERP与自杀意念的相关性。
共招募了162名参与者（104名有自杀意念的患者、31名无自杀意念的患者和27名健康对照者），并在脑电图测量期间进行GoNogo任务。通过自评量表评估抑郁、焦虑、自杀意念和冲动性。对各组的临床指标、行为数据和Nogo ERP进行比较。
与无自杀意念的MDD组（Fz和Cz电极）及对照组（所有电极）相比，有自杀意念（SI）的MDD组Nogo P3波幅显著降低。与无自杀意念的MDD组相比，有SI的MDD组在Go和Nogo试验中的准确率也显著较低。Nogo P3波幅与冲动性、抑郁、焦虑和SI评分呈负相关。
我们的结果表明，与无自杀意念的MDD患者及对照组相比，有自杀意念的MDD患者Nogo P3 ERP波幅降低。这些发现表明，Nogo P3波幅降低是评估MDD患者冲动性以预测自杀意念的候选生物标志物之一。
