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一例罕见的胫骨远端和腓骨侵袭性多发性非骨化性纤维瘤:病例报告

An unusually aggressive multiple non-ossifying fibroma of the distal tibia and fibula: A case report.

作者信息

Bouaicha Walid, Jlidi Mohamed, Nechi Salwa, Lammouchi Mouldi, Sbaihi Siwar, Daas Selim

机构信息

Orthopaedics and Trauma department, M.T.M Hospital, Nabeul, Tunisia.

University of Tunis el Manar, Faculty of Medicine of Tunis, Tunisia.

出版信息

Bone Rep. 2023 Oct 11;19:101721. doi: 10.1016/j.bonr.2023.101721. eCollection 2023 Dec.

DOI:10.1016/j.bonr.2023.101721
PMID:37859796
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10582832/
Abstract

BACKGROUND AND PURPOSE

Non-ossifying fibroma (NOF) is one of the most commonly seen benign bone tumours. Although renowned for their benign behaviour and tendency for spontaneous healing, these tumours can occasionally exhibit an aggressive course. Few published papers have focused on the treatment options of symptomatic NOFs.The aim of this case report is to discuss the clinical presentation of a painful and unusually aggressive multiple NOF of the distal tibia in a female adolescent patient.

CASE PRESENTATION

The case of a 17-year-old female patient who was complaining of a painful swollen right lower leg for the past few months. The symptoms became gradually worse, preventing her from sporting activities and becoming more and more debilitating. The patient was diagnosed with a particularly aggressive multiple non-ossifying fibroma of the distal tibia and fibula. She was treated with lesion curettage, bone grafting and external fixation with good clinical and radiological outcomes.

CONCLUSION

Non-ossifying fibroma is a benign lesion that only requires observation in most of the cases. However, symptomatic lesions with aggressive behaviour or complicated with pathologic fracture may warrant surgical intervention.

摘要

背景与目的

非骨化性纤维瘤(NOF)是最常见的良性骨肿瘤之一。尽管这些肿瘤以其良性行为和自发愈合倾向而闻名,但它们偶尔也会表现出侵袭性病程。很少有已发表的论文关注有症状的非骨化性纤维瘤的治疗选择。本病例报告的目的是讨论一名女性青少年患者右胫骨远端疼痛且异常侵袭性的多发性非骨化性纤维瘤的临床表现。

病例介绍

一名17岁女性患者,主诉在过去几个月里右小腿疼痛肿胀。症状逐渐加重,使她无法进行体育活动,且日益衰弱。该患者被诊断为右胫骨远端和腓骨特别侵袭性的多发性非骨化性纤维瘤。她接受了病灶刮除、骨移植和外固定治疗,临床和影像学结果良好。

结论

非骨化性纤维瘤是一种良性病变,大多数情况下仅需观察。然而,具有侵袭性行为或并发病理性骨折的有症状病变可能需要手术干预。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a040/10582832/39de8a8a4c23/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a040/10582832/f5caa0d86709/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a040/10582832/30874b2a2857/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a040/10582832/67ef73373e04/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a040/10582832/8cce1dab58d2/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a040/10582832/39de8a8a4c23/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a040/10582832/f5caa0d86709/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a040/10582832/30874b2a2857/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a040/10582832/67ef73373e04/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a040/10582832/8cce1dab58d2/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a040/10582832/39de8a8a4c23/gr5.jpg

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Cureus. 2023 Mar 21;15(3):e36470. doi: 10.7759/cureus.36470. eCollection 2023 Mar.
2
Non-ossifying fibromas and fibrous cortical defects around the knee - an epidemiologic survey in a Japanese pediatric population.膝关节周围非骨化性纤维瘤和纤维性皮质缺损:日本儿科人群的一项流行病学调查。
BMC Musculoskelet Disord. 2022 Apr 22;23(1):378. doi: 10.1186/s12891-022-05330-9.
3
Imaging of Non-ossifying Fibromas: A Case Series.非骨化性纤维瘤的影像学表现:病例系列
Cureus. 2021 Mar 25;13(3):e14102. doi: 10.7759/cureus.14102.
4
Non-ossifying fibroma: A RAS-MAPK driven benign bone neoplasm.非骨化性纤维瘤:一种 RAS-MAPK 驱动的良性骨肿瘤。
J Pathol. 2019 Jun;248(2):127-130. doi: 10.1002/path.5259. Epub 2019 Mar 20.
5
Activating mutations in the MAP-kinase pathway define non-ossifying fibroma of bone.MAP-激酶通路中的激活突变定义了骨非骨化性纤维瘤。
J Pathol. 2019 May;248(1):116-122. doi: 10.1002/path.5216. Epub 2019 Jan 24.
6
CLINICAL REASONING IN THE FACE OF UNCERTAINTY: CONSERVATIVE PHYSICAL THERAPY MANAGEMENT OF A TEENAGE ATHLETE DIAGNOSED WITH A PROXIMAL HUMERAL NON-OSSIFYING FIBROMA.面对不确定性时的临床推理:一名被诊断为肱骨近端非骨化性纤维瘤的青少年运动员的保守物理治疗管理
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