Department of Orthopedic Surgery, Sapporo Medical University School of Medicine, West 16, South 1, Chuo- ku, Sapporo, Hokkaido, 060-8543, Japan.
Department of Orthopedic Surgery, Akita University School of Medicine, Akita, Akita, 010-8543, Japan.
BMC Musculoskelet Disord. 2022 Apr 22;23(1):378. doi: 10.1186/s12891-022-05330-9.
The aim of the present study was to evaluate the prevalence of non-ossifying fibroma (NOF) and fibrous cortical defect (FCD) in a Japanese pediatric population and the association between the lesion size and pain.
This retrospective study, conducted across 10 Japanese institutions, included patients aged 5-15 years who had undergone standard antero-posterior and lateral view radiography of the knee. Using these radiographs, we diagnosed the lesion as a NOF or FCD. Patient demographics, including age, sex, the size and location of the NOF, and chief complaint were recorded. The lesion size was determined using radiographs. Student's t-test was used to compare the associations between the lesion size and spontaneous pain.
A total of 6222 subjects (3567 boys and 2455 girls) were included in this study. The number of NOF and FCD cases was 143 and 437, respectively, and the prevalence of NOF and FCD was 2.3% and 7.0%, respectively. The average size of NOF and FCD was 22.1 mm (range: 4-102 mm) and 13.2 mm (range: 5-21 mm), respectively. Three patients (2.1%) had pathological fractures due to NOF. Of the 140 NOFs and 437 FCDs, we obtained complaints from the medical records of 126 and 393 patients, respectively. The number of patients with spontaneous pain or other problems with NOF was 68 (54%) and 58 (46%), respectively, that of patients with FCD was 195 (50%) and 198 (50%) patients, respectively. The lesion size was not associated with spontaneous pain in either lesion (p = 0.67 and p = 0.27, respectively).
The prevalence of NOF and FCD around the knee was lower than that reported in previous studies. The prevalence of NOF increased and that of FCD decreased with advancing age. In both lesions, the lesion size may not be associated with pain.
本研究旨在评估非骨化性纤维瘤（NOF）和纤维皮质缺损（FCD）在日本儿科人群中的患病率，并探讨病变大小与疼痛之间的关系。
这是一项回顾性研究，在日本的 10 家机构进行，纳入了年龄在 5-15 岁之间、接受过膝关节标准前后位和侧位 X 线摄影的患者。使用这些 X 线片，我们将病变诊断为 NOF 或 FCD。记录患者的人口统计学数据，包括年龄、性别、NOF 的大小和位置以及主要诉求。病变大小通过 X 线片确定。采用 Student's t 检验比较病变大小与自发性疼痛之间的关系。
本研究共纳入 6222 名受试者（男 3567 名，女 2455 名）。NOF 和 FCD 的病例数分别为 143 例和 437 例，NOF 和 FCD 的患病率分别为 2.3%和 7.0%。NOF 和 FCD 的平均大小分别为 22.1mm（范围：4-102mm）和 13.2mm（范围：5-21mm）。3 例（2.1%）因 NOF 发生病理性骨折。在 140 例 NOF 和 437 例 FCD 中，我们从病历中获得了 126 例和 393 例患者的投诉。NOF 有自发性疼痛或其他问题的患者分别为 68 例（54%）和 58 例（46%），FCD 有自发性疼痛或其他问题的患者分别为 195 例（50%）和 198 例（50%）。病变大小与两种病变的自发性疼痛均无相关性（p=0.67 和 p=0.27）。
膝关节周围的 NOF 和 FCD 的患病率低于既往研究报道。NOF 的患病率随年龄增长而增加，FCD 的患病率随年龄增长而降低。在两种病变中，病变大小可能与疼痛无关。
