NOTCH1表达增加与中/低分化人类口腔鳞状细胞癌患者的低生存率相关。
Increased NOTCH1 expression is associated with low survival in moderate/ poor differentiated human oral squamous cell carcinoma patients.
作者信息
Mohammedsaleh Zuhair M, Moawadh Mamdoh S, Saleh Fayez M, Jalal Mohammed M, Al-Otaibi Abdulaziz S, Saeedi Nizar H, Baskaran Rathinasamy, Huang Chih-Yang, Kumar V Bharath
机构信息
Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, University of Tabuk, Tabuk 71491, Saudi Arabia.
Department of Medical Microbiology, Faculty of Medicine, University of Tabuk, Tabuk 71491, Saudi Arabia.
出版信息
J Cancer. 2023 Sep 18;14(16):3023-3027. doi: 10.7150/jca.87128. eCollection 2023.
Notch deregulation has been reported in various types of cancers, including Oral squamous cell carcinomas (OSCCs). The role of Notch1 signaling in oral squamous cell carcinoma (OSCC) remains poorly understood. In this study, NOTCH1 was aberrantly expressed in human oral cancer tissues compared with that in normal marginal tissues and was associated with poor prognosis. The positive Notch 1 expression was significantly associated with poor tumor differentiation status. Kaplan-Meier survival curves revealed that elevated cytoplasmic NOTCH1 expression levels in OSCC patients were associated with poor overall survival. Moreover, multivariate COX proportional hazard models revealed that T N status, AJCC stage histological grade were independent prognostic factors for survival. Our result clearly demonstrates the oncogenic role of Notch1 in oral cancer and Notch1 may be a useful biomarker to target oral cancer patients.
据报道，Notch失调存在于包括口腔鳞状细胞癌（OSCC）在内的多种癌症类型中。Notch1信号通路在口腔鳞状细胞癌（OSCC）中的作用仍知之甚少。在本研究中，与正常边缘组织相比，NOTCH1在人类口腔癌组织中异常表达，且与预后不良相关。Notch 1阳性表达与肿瘤分化不良状态显著相关。Kaplan-Meier生存曲线显示，OSCC患者细胞质NOTCH1表达水平升高与总体生存率低相关。此外，多变量COX比例风险模型显示，T N状态、AJCC分期组织学分级是生存的独立预后因素。我们的结果清楚地证明了Notch1在口腔癌中的致癌作用，Notch1可能是针对口腔癌患者的有用生物标志物。
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