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老年女性广泛头皮黑色素瘤:病例报告及文献综述

Extensive Scalp Melanoma in an Elderly Female: A Case Report and Literature Review.

作者信息

Francis Maya A, Shaikh Rahila, Inban Pugazhendi, Akuma Ogbonnaya, Intsiful Tarsha A, Akuma Chinaza M, Lat Aung Lynn Lat, Chukwuedozie Vivian C, Francis Sandra, Sukhoroslov Mikhail

机构信息

Internal Medicine, Windsor University School of Medicine, Cayon, KNA.

Dermatology/Internal Medicine, Saba University School of Medicine, The Bottom, BES.

出版信息

Cureus. 2023 Sep 17;15(9):e45425. doi: 10.7759/cureus.45425. eCollection 2023 Sep.

DOI:10.7759/cureus.45425
PMID:37859876
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10581861/
Abstract

Scalp melanoma is a rare and aggressive form of skin cancer. Its occurrence in the elderly population poses unique challenges due to factors such as delayed diagnosis and comorbidities. We present a case of extensive scalp melanoma in an elderly female to highlight the clinical presentation, diagnostic process, treatment modalities, and outcomes. Biopsy and histopathological analysis showed the presence of dysplastic nevi arising in pigmented melanocytic nevi, with uncertain pagetoid spread of atypical melanocytes. The management involved complete excision with safety margins and immunotherapy based on melanoma guidelines. This case underscores the importance of early detection and tailored treatment strategies in managing melanoma in elderly patients.

摘要

头皮黑色素瘤是一种罕见且侵袭性强的皮肤癌形式。由于诊断延迟和合并症等因素,其在老年人群中的发生带来了独特的挑战。我们报告一例老年女性广泛头皮黑色素瘤病例,以突出临床表现、诊断过程、治疗方式及结果。活检和组织病理学分析显示,色素性黑素细胞痣中出现发育异常痣,非典型黑素细胞呈不确定的派杰样播散。治疗包括按照黑色素瘤诊疗指南进行安全切缘的完整切除及免疫治疗。该病例强调了老年患者黑色素瘤管理中早期检测和个性化治疗策略的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fbe4/10581861/fd7cb2cca2eb/cureus-0015-00000045425-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fbe4/10581861/f3bfa1c223e0/cureus-0015-00000045425-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fbe4/10581861/fd7cb2cca2eb/cureus-0015-00000045425-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fbe4/10581861/f3bfa1c223e0/cureus-0015-00000045425-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fbe4/10581861/fd7cb2cca2eb/cureus-0015-00000045425-i02.jpg

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引用本文的文献

1
Rapidly progressing scalp melanoma in an elderly patient.一名老年患者的快速进展性头皮黑色素瘤。
Skin Health Dis. 2024 Jul 22;4(5):e431. doi: 10.1002/ski2.431. eCollection 2024 Oct.

本文引用的文献

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Strategies to Improve Adherence to Skin Self-examination and Other Self-management Practices in People at High Risk of Melanoma: A Scoping Review of Randomized Clinical Trials.提高黑色素瘤高危人群皮肤自我检查及其他自我管理措施依从性的策略:一项随机临床试验的范围综述
JAMA Dermatol. 2023 Apr 1;159(4):432-440. doi: 10.1001/jamadermatol.2022.6478.
2
European consensus-based interdisciplinary guideline for melanoma. Part 2: Treatment - Update 2022.欧洲基于共识的多学科黑色素瘤指南。第 2 部分:治疗 - 2022 更新。
Eur J Cancer. 2022 Jul;170:256-284. doi: 10.1016/j.ejca.2022.04.018. Epub 2022 May 24.
3
Diagnosis and Management of Melanoma of the Scalp: A Review of the Literature.
头皮黑色素瘤的诊断与管理:文献综述
Clin Cosmet Investig Dermatol. 2021 Oct 7;14:1435-1447. doi: 10.2147/CCID.S293115. eCollection 2021.
4
Not all melanomas are created equal: a review and call for more research into nodular melanoma.并非所有的黑色素瘤都是一样的:对结节性黑色素瘤的回顾和呼吁进行更多研究。
Br J Dermatol. 2021 Oct;185(4):700-710. doi: 10.1111/bjd.20388. Epub 2021 Jul 14.
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Association of Known Melanoma Risk Factors with Primary Melanoma of the Scalp and Neck.已知黑素瘤危险因素与头皮和颈部原发性黑素瘤的关系。
6
Improving the early diagnosis of early nodular melanoma: can we do better?提高早期结节性黑素瘤的早期诊断:我们能否做得更好?
Expert Rev Anticancer Ther. 2018 Oct;18(10):1007-1012. doi: 10.1080/14737140.2018.1507822. Epub 2018 Aug 13.
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[Melanoma secondary prevention].[黑色素瘤二级预防]
Rev Med Brux. 2015 Sep;36(4):255-9.
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[Histological spectrum of malignant melanoma].[恶性黑色素瘤的组织学谱]
Pathologe. 2015 Feb;36(1):53-61. doi: 10.1007/s00292-014-2001-4.
9
Melanoma patient self-detection: a review of efficacy of the skin self-examination and patient-directed educational efforts.黑色素瘤患者自我检测:皮肤自我检查和患者导向教育效果的综述。
Expert Rev Anticancer Ther. 2013 Dec;13(12):1423-31. doi: 10.1586/14737140.2013.856272.
10
Survival differences between patients with scalp or neck melanoma and those with melanoma of other sites in the Surveillance, Epidemiology, and End Results (SEER) program.监测、流行病学和最终结果(SEER)计划中头皮或颈部黑色素瘤患者与其他部位黑色素瘤患者的生存差异。
Arch Dermatol. 2008 Apr;144(4):515-21. doi: 10.1001/archderm.144.4.515.