First Department of Dermatology-Venereology, National and Kapodistrian University of Athens, Athens, Greece.
Department of Social and Behavioral Sciences, Harvard TH Chan School of Public Health, Boston, MA, USA.
Br J Dermatol. 2021 Oct;185(4):700-710. doi: 10.1111/bjd.20388. Epub 2021 Jul 14.
Among the histogenic subtypes of melanoma, nodular melanoma (NM) is the major contributor for thicker and fatal melanomas and it has been associated with melanoma-specific death in thin tumours, highlighting an important subgroup of 'aggressive thin' melanomas. This review provides a synthesis of the distinct characteristics of NM, with respect to epidemiology and risk factors, clinical presentation, histopathology, molecular and dermoscopic aspects, and screening practices. The real challenges are to find better biomarkers of aggressiveness and to know whether the control of such aggressive melanomas can be influenced by targeted interventions such as early detection, drug interventions and preventive strategies.
在黑色素瘤的组织学亚型中，结节性黑色素瘤（NM）是导致较厚和致命性黑色素瘤的主要原因，并且与薄型肿瘤中的黑色素瘤特异性死亡相关，突出了“侵袭性薄型”黑色素瘤的一个重要亚组。本综述提供了 NM 的独特特征的综合，包括流行病学和危险因素、临床表现、组织病理学、分子和皮肤镜方面以及筛查实践。真正的挑战是找到更好的侵袭性生物标志物，并了解是否可以通过早期检测、药物干预和预防策略等靶向干预来控制这种侵袭性黑色素瘤。
