Elegbe R A
Biochem Exp Biol. 1978;14(2):158-66.
Experimental models of chronic and acute peptic ulcerations were produced in the albino rats by means of prolonged starvation and indomethacin administration. In the case of acute indomethacin-induced peptic ulceration, the effects of anticholinergic drugs on the ulcers produced were also studied. Starving the rats for a period of seven days produced gastric ulceration in all the rats used while indomethacin produced gastric ulceration within five hours in all the rats used. Severe ulceration of the degree found in human peptic ulcer disease was produced only by chronic starvation. Anticholinergic drugs ameliorated indomethacin-induced gastric ulceration, partly at least, by reducing intra-gastric acidity.
通过长期饥饿和给予吲哚美辛，在白化大鼠中建立慢性和急性消化性溃疡的实验模型。对于急性吲哚美辛诱导的消化性溃疡，还研究了抗胆碱能药物对所产生溃疡的影响。使大鼠饥饿7天，所有使用的大鼠均出现胃溃疡；而给予吲哚美辛，所有使用的大鼠在5小时内出现胃溃疡。仅慢性饥饿会产生人类消化性溃疡疾病中所见程度的严重溃疡。抗胆碱能药物至少部分地通过降低胃内酸度来改善吲哚美辛诱导的胃溃疡。
