de Barros Muriel Primon, Sousa João Paulo Barreto, Bastos Jairo Kenupp, de Andrade Sérgio Faloni
Núcleo de Ciência e Tecnologia, Area de Ciências Biológicas e da Saúde, Universidade do Oeste de Santa Catarina, Campus de Videira, SC, Brazil.
J Ethnopharmacol. 2007 Apr 4;110(3):567-71. doi: 10.1016/j.jep.2006.10.022. Epub 2006 Oct 28.
Propolis is a resinous hive product collected by honeybees from plants. The propolis produced in Southeastern of Brazil is known as green propolis because of its color. Modern herbalists recommend its use because it displays antibacterial, antifungal, antiviral, hepatoprotective, anti-inflammatory, immunomodulatory and anti-ulcer properties. The anti-ulcer activity of green propolis hydroalcoholic crude extract was evaluated by using models of acute gastric lesions induced by ethanol, indomethacin and stress in rats. Moreover, the effects of extract on gastric content volume, pH and total acidity, using pylorus ligated model were evaluated. Animals pretreated with propolis hydroalcoholic crude extract (50, 250 and 500 mg/kg) showed a significant reduction in lesion index, total affected area and percentage of lesion in comparison with control group (p<0.05) in the ethanol-induced ulcer model. Green propolis extract, at a higher dose (500 mg/kg), displayed a significant protection by reducing (p<0.05) the evaluated parameters in the gastric ulceration induced by indomethacin. In the stress-induced ulcer model it was observed a significant reduction (p<0.05) in those parameters in animals treated with green propolis extract (250 and 500 mg/kg). Regarding the pylorus ligated model it was observed that green propolis extract (250 and 500 mg/kg) displayed an anti-secretory activity, which lead to a reduction in the gastric juice volume, total acidity and pH. These findings indicate that Brazilian green propolis displays good anti-ulcer activity, corroborating the folk use of propolis preparations, and contributing for its pharmacological validation.
蜂胶是蜜蜂从植物中采集的一种树脂状蜂箱产品。巴西东南部生产的蜂胶因其颜色而被称为绿蜂胶。现代草药医生推荐使用它，因为它具有抗菌、抗真菌、抗病毒、保肝、抗炎、免疫调节和抗溃疡特性。通过使用乙醇、吲哚美辛和应激诱导大鼠急性胃损伤的模型，评估了绿蜂胶水醇粗提物的抗溃疡活性。此外，使用幽门结扎模型评估了提取物对胃内容物体积、pH值和总酸度的影响。在乙醇诱导的溃疡模型中，用蜂胶水醇粗提物（50、250和500mg/kg）预处理的动物与对照组相比，病变指数、总受累面积和病变百分比显著降低（p<0.05）。在吲哚美辛诱导的胃溃疡中，高剂量（500mg/kg）的绿蜂胶提取物通过降低（p<0.05）评估参数显示出显著的保护作用。在应激诱导的溃疡模型中，观察到用绿蜂胶提取物（250和500mg/kg）处理的动物的这些参数显著降低（p<0.05）。关于幽门结扎模型，观察到绿蜂胶提取物（250和500mg/kg）具有抗分泌活性，导致胃液体积、总酸度和pH值降低。这些发现表明，巴西绿蜂胶具有良好的抗溃疡活性，证实了民间对蜂胶制剂的使用，并为其药理验证做出了贡献。
