Vazquez Manuel, Vassil Alana, Sirotkin Igor
University of Central Florida College of Medicine, Orlando.
University of South Florida Morsani College of Medicine, Tampa.
Fed Pract. 2023 Jun;40(6):182-185. doi: 10.12788/fp.0382. Epub 2023 Jun 15.
Pyogenic hepatic abscess (PHA) is a collection of pus in the liver caused by bacterial infection of the liver parenchyma. PHA is more common in immunosuppressed individuals and those with diabetes mellitus, cancer, and liver transplant.
We present a rare case of PHA with in an immunocompetent patient with poor oral health, history of diverticulitis, and recent COVID-19 infection whose only symptoms were chest pain and a 4-week history of fever and malaise. The source of infection in this patient was likely dental caries and periodontal disease, with COVID-19 infection playing a role as a red herring in this patient's disease progression, delaying diagnosis.
Diagnosis and treatment of PHA must be prompt with drainage and empiric anaerobic coverage followed by a more tailored antibiotic regimen if indicated by culture and further drainage if indicated by computed tomography.
化脓性肝脓肿(PHA)是肝实质细菌感染导致肝脏内的脓液聚集。PHA在免疫功能低下个体以及患有糖尿病、癌症和肝移植患者中更为常见。
我们报告一例罕见的PHA病例,患者免疫功能正常,但口腔卫生差,有憩室炎病史,近期感染过新冠病毒,其唯一症状为胸痛以及持续4周的发热和不适。该患者的感染源可能是龋齿和牙周疾病,新冠病毒感染在该患者疾病进展过程中起到干扰作用,延误了诊断。
PHA的诊断和治疗必须迅速,进行引流并经验性覆盖厌氧菌,若培养结果有指征则采用更具针对性的抗生素方案,若计算机断层扫描有指征则进一步引流。