不同果汁对人体粪便体外发酵的微生物群调节作用。
Microbiota regulation by different fruit juices upon human fecal fermentation in vitro.
作者信息
Sun Yuhao, Hu Yaru, Hu Danqi, Xiao Zhuqian, Wang Hongpeng, Huang Jun, Mao Jianwei
机构信息
Zhejiang Provincial Key Laboratory for Chemical and Biological Processing Technology of Farm Products, School of Biological and Chemical Engineering, Zhejiang University of Science and Technology, Hangzhou, 310023 China.
出版信息
Food Sci Biotechnol. 2023 Apr 24;32(14):2093-2104. doi: 10.1007/s10068-023-01308-y. eCollection 2023 Dec.
UNLABELLED
Three different fruit juices were prepared, and their effects on modulation of human fecal microbiota were elucidated through an anaerobic fermentation in vitro. Results indicated that the introduction of inoculatedly-fermented fruit juice promoted short-chain fatty acids productivity. Fecal microbiota analysis demonstrated up-regulations for abundances of , , , and , and down-regulations for numbers of , , , and . Correlation analysis confirmed relationships among sample components, short-chain fatty acids productivity, and microbial abundances, suggesting that sugars and organic acids stimulated growth of and suppressed proliferation of , thus uncovering the underlying mechanism for the better ability of inoculatedly-fermented fruit juice to regulate microbiota structure. Besides, clusters of orthologous groups of proteins analysis indicated that metabolite biosynthesis, energy metabolism, homeostasis maintenance and other physiological functions were ameliorated.
SUPPLEMENTARY INFORMATION
The online version contains supplementary material available at 10.1007/s10068-023-01308-y.
未标记
制备了三种不同的果汁，并通过体外厌氧发酵阐明了它们对人类粪便微生物群调节的影响。结果表明，接种发酵果汁的引入提高了短链脂肪酸的生产率。粪便微生物群分析表明，[具体微生物名称1]、[具体微生物名称2]、[具体微生物名称3]和[具体微生物名称4]的丰度上调，而[具体微生物名称5]、[具体微生物名称6]、[具体微生物名称7]和[具体微生物名称8]的数量下调。相关性分析证实了样品成分、短链脂肪酸生产率和微生物丰度之间的关系，表明糖和有机酸刺激了[具体微生物名称9]的生长并抑制了[具体微生物名称10]的增殖，从而揭示了接种发酵果汁调节微生物群结构能力更强的潜在机制。此外，直系同源蛋白簇分析表明，代谢物生物合成、能量代谢、稳态维持和其他生理功能得到改善。
补充信息
在线版本包含可在10.1007/s10068-023-01308-y获取的补充材料。
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