To err, K2 that is, on the side of vasodilation in aging.
作者信息
Bernardino de Paula Ricardo, Wenceslau Camilla F, McCarthy Cameron G
机构信息
Cardiovascular Translational Research Center and Department of Cell Biology and Anatomy, University of South Carolina School of Medicine, Columbia, South Carolina, United States.
出版信息
Am J Physiol Heart Circ Physiol. 2023 Dec 1;325(6):H1415-H1417. doi: 10.1152/ajpheart.00670.2023. Epub 2023 Oct 20.
Abstract
摘要
相似文献
1
To err, K2 that is, on the side of vasodilation in aging.也就是说，在衰老过程中倾向于血管舒张方面出错（即倾向于血管舒张方面犯错）。这里的K2不太明确其准确含义，只能根据大致意思翻译。推测可能是在某个关于衰老和血管舒张的研究或理论中有特定指代的一个概念、因子之类的。 （注：以上括号内内容不是翻译内容，只是为了更好解释译文做的说明）
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本文引用的文献
1
Endothelial K2 channel dysfunction in aged cerebral parenchymal arterioles.老年脑实质小动脉中的内皮K2通道功能障碍。
Am J Physiol Heart Circ Physiol. 2023 Oct 6;325(6):H1360-72. doi: 10.1152/ajpheart.00279.2023.
2
Functional vascular contributions to cognitive impairment and dementia: mechanisms and consequences of cerebral autoregulatory dysfunction, endothelial impairment, and neurovascular uncoupling in aging.功能血管对认知障碍和痴呆的影响：衰老过程中脑自动调节功能障碍、内皮功能损伤及神经血管解偶联的机制与后果
Am J Physiol Heart Circ Physiol. 2017 Jan 1;312(1):H1-H20. doi: 10.1152/ajpheart.00581.2016. Epub 2016 Oct 28.
3
EDH: endothelium-dependent hyperpolarization and microvascular signalling.EDH：内皮依赖性超极化和微血管信号转导。
Acta Physiol (Oxf). 2017 Jan;219(1):152-161. doi: 10.1111/apha.12649. Epub 2016 Feb 1.
4
Increased pressure-induced tone in rat parenchymal arterioles vs. middle cerebral arteries: role of ion channels and calcium sensitivity.大鼠实质小动脉与大脑中动脉压力诱导张力增加的比较：离子通道和钙敏感性的作用
J Appl Physiol (1985). 2014 Jul 1;117(1):53-9. doi: 10.1152/japplphysiol.00253.2014. Epub 2014 May 1.
5
Purinergic receptors regulate myogenic tone in cerebral parenchymal arterioles.嘌呤能受体调节脑实质小动脉的肌源性张力。
J Cereb Blood Flow Metab. 2013 Feb;33(2):293-9. doi: 10.1038/jcbfm.2012.169. Epub 2012 Nov 21.
6
ATP hydrolysis pathways and their contributions to pial arteriolar dilation in rats.三磷酸腺苷水解途径及其对大鼠软脑膜小动脉扩张的贡献。
Am J Physiol Heart Circ Physiol. 2011 Oct;301(4):H1369-77. doi: 10.1152/ajpheart.00556.2011. Epub 2011 Jul 29.
7
Age-related alterations in reactivity of cerebral arterioles: role of oxidative stress.脑小动脉反应性的年龄相关性改变：氧化应激的作用。
Microcirculation. 2008 Apr;15(3):225-36. doi: 10.1080/10739680701641421.
8
Penetrating arterioles are a bottleneck in the perfusion of neocortex.穿透小动脉是新皮质灌注的一个瓶颈。
Proc Natl Acad Sci U S A. 2007 Jan 2;104(1):365-70. doi: 10.1073/pnas.0609551104. Epub 2006 Dec 26.
9
Age-related changes in P2 receptor mRNA of rat cerebral arteries.大鼠脑动脉P2受体mRNA的年龄相关变化。
Exp Gerontol. 2001 Dec;37(1):67-79. doi: 10.1016/s0531-5565(01)00159-0.
10
Extracellular K(+)-induced hyperpolarizations and dilatations of rat coronary and cerebral arteries involve inward rectifier K(+) channels.细胞外钾离子诱导的大鼠冠状动脉和脑动脉超极化及扩张涉及内向整流钾通道。
J Physiol. 1996 Apr 15;492 ( Pt 2)(Pt 2):419-30. doi: 10.1113/jphysiol.1996.sp021318.
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