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麦角铁制剂的一般毒性分析。

Analysis of General Toxicity of Ergoferon.

作者信息

Danchenko E A, Ertuzun I A, Bugaeva L I, Lebedeva S A, Denisova T D, Lavrova E B, Korzhova T M, Tarasov S A

机构信息

LLC "MATERIA MEDICA HOLDING", Moscow, Russia.

Volgograd State Medical University, Ministry of Health of the Russian Federation, Volgograd, Russia.

出版信息

Bull Exp Biol Med. 2023 Sep;175(5):644-648. doi: 10.1007/s10517-023-05918-8. Epub 2023 Oct 20.

Abstract

For antibody-based drugs, it is important and relevant to study their toxic effects, which can often become limiting when prescribing this type of therapy. General toxicity of antiviral drug Ergoferon based on technologically processed antibodies was studied on sexually mature animals. Analysis of acute toxicity showed the absence of lethal outcomes when the drug was administered to adult rats at the maximum tolerated doses. In a study of repeated dose toxicity, no adverse effects of the drug were detected.

摘要

对于基于抗体的药物,研究其毒性作用很重要且具有现实意义,在开具这类治疗药物处方时,毒性作用往往会成为限制因素。在性成熟动物身上研究了基于经技术处理抗体的抗病毒药物Ergoferon的一般毒性。急性毒性分析表明,以最大耐受剂量给成年大鼠给药该药物时未出现致死情况。在重复剂量毒性研究中,未检测到该药物的不良反应。

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