Department of Toxicology and Pharmacology, Faculty of Pharmacy, and Pharmaceutical Sciences Research Center (PSRC), Tehran University of Medical Sciences, Tehran, Iran.
Department of Pharmacoeconomics and Pharmaceutical Administration, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
Expert Opin Drug Metab Toxicol. 2023 Jul-Dec;19(11):807-828. doi: 10.1080/17425255.2023.2273384. Epub 2023 Nov 17.
Polypharmacy, which uses multiple medications to treat chronic illnesses, is common among elderly patients. However, it can lead to drug interactions, especially with gastrointestinal (GI) medicines that are extensively used. These drug interactions can have severe consequences and pose a significant challenge to healthcare providers. Therefore, it is crucial to identify the underlying mechanisms of these interactions and develop strategies to minimize medication errors.
We analyzed databases on GI illnesses common in older adults, including GERD, peptic ulcer disease, IBS, IBD, constipation, and diarrhea. Our research identified noteworthy drug interactions and utilized major electronic databases such as USFDA, PubMed, Scopus, and Google Scholar until 15 May 202315 May 2023, along with a review of reference lists.
Aging can affect how the body processes drugs, leading to an increased risk of drug interactions. Therefore, healthcare professionals must carefully evaluate a patient's medical history and health condition to design personalized treatment plans.
多药疗法是指使用多种药物来治疗慢性病，在老年患者中较为常见。然而，它可能会导致药物相互作用，尤其是与广泛使用的胃肠道（GI）药物。这些药物相互作用可能会产生严重后果，并对医疗保健提供者构成重大挑战。因此，确定这些相互作用的潜在机制并制定策略以最小化药物错误至关重要。
我们分析了老年人常见的胃肠道疾病数据库，包括 GERD、消化性溃疡病、IBS、IBD、便秘和腹泻。我们的研究确定了值得注意的药物相互作用，并利用了美国 FDA、PubMed、Scopus 和 Google Scholar 等主要电子数据库，直到 2023 年 5 月 15 日，同时查阅了参考文献列表。
年龄的增长会影响身体处理药物的方式，从而增加药物相互作用的风险。因此，医疗保健专业人员必须仔细评估患者的病史和健康状况，以制定个性化的治疗计划。
