Liu Chengli, Wang Guijun, Han Wenrui, Tian Qi, Li Mingchang
Department of Neurosurgery, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China.
Neural Regen Res. 2024 May;19(5):988-997. doi: 10.4103/1673-5374.385284.
Ferroptosis is a form of regulated cell death characterized by massive iron accumulation and iron-dependent lipid peroxidation, differing from apoptosis, necroptosis, and autophagy in several aspects. Ferroptosis is regarded as a critical mechanism of a series of pathophysiological reactions after stroke because of iron overload caused by hemoglobin degradation and iron metabolism imbalance. In this review, we discuss ferroptosis-related metabolisms, important molecules directly or indirectly targeting iron metabolism and lipid peroxidation, and transcriptional regulation of ferroptosis, revealing the role of ferroptosis in the progression of stroke. We present updated progress in the intervention of ferroptosis as therapeutic strategies for stroke in vivo and in vitro and summarize the effects of ferroptosis inhibitors on stroke. Our review facilitates further understanding of ferroptosis pathogenesis in stroke, proposes new targets for the treatment of stroke, and suggests that more efforts should be made to investigate the mechanism of ferroptosis in stroke.
铁死亡是一种程序性细胞死亡形式，其特征是大量铁蓄积和铁依赖性脂质过氧化，在多个方面与细胞凋亡、坏死性凋亡和自噬不同。由于血红蛋白降解和铁代谢失衡导致的铁过载，铁死亡被认为是中风后一系列病理生理反应的关键机制。在这篇综述中，我们讨论了与铁死亡相关的代谢、直接或间接靶向铁代谢和脂质过氧化的重要分子以及铁死亡的转录调控，揭示了铁死亡在中风进展中的作用。我们介绍了铁死亡干预作为体内外中风治疗策略的最新进展，并总结了铁死亡抑制剂对中风的影响。我们的综述有助于进一步了解中风中铁死亡的发病机制，提出中风治疗的新靶点，并表明应更加努力研究中风中铁死亡的机制。
