Fang Xiao-Ling, Ding Shao-Yun, Du Xiao-Zheng, Wang Jin-Hai, Li Xing-Lan
College of Acupuncture and Massage, Gansu University of Traditional Chinese Medicine, Lanzhou, China.
Department of Traditional Chinese Medicine, The Second Hospital of Lanzhou University, Lanzhou, China.
Front Neurol. 2022 Apr 11;13:881809. doi: 10.3389/fneur.2022.881809. eCollection 2022.
As a neurological disease with high morbidity, disability, and mortality, the pathological mechanism underlying stroke involves complex processes such as neuroinflammation, oxidative stress, apoptosis, autophagy, and excitotoxicity; but the related research on these molecular mechanisms has not been effectively applied in clinical practice. As a form of iron-dependent regulated cell death, ferroptosis was first discovered in the pathological process of cancer, but recent studies have shown that ferroptosis is closely related to the onset and development of stroke. Therefore, a deeper understanding of the relationship between ferroptosis and stroke may lead to more effective treatment strategies. Herein, we reviewed the mechanism(s) underlying the onset of ferroptosis in stroke, the potential role of ferroptosis in stroke, and the crosstalk between ferroptosis and other pathological mechanisms. This will further deepen our understanding of ferroptosis and provide new approaches to the treatment of stroke.
作为一种发病率、致残率和死亡率都很高的神经系统疾病，中风的病理机制涉及神经炎症、氧化应激、细胞凋亡、自噬和兴奋性毒性等复杂过程；但这些分子机制的相关研究尚未在临床实践中得到有效应用。作为一种铁依赖性调节性细胞死亡形式，铁死亡最初是在癌症的病理过程中被发现的，但最近的研究表明，铁死亡与中风的发生和发展密切相关。因此，更深入地了解铁死亡与中风之间的关系可能会带来更有效的治疗策略。在此，我们综述了中风中铁死亡发生的机制、铁死亡在中风中的潜在作用以及铁死亡与其他病理机制之间的相互作用。这将进一步加深我们对铁死亡的理解，并为中风治疗提供新的方法。
