白藜芦醇：生物学、代谢及对结直肠癌肿瘤微环境的有害作用。

Resveratrol: biology, metabolism, and detrimental role on the tumor microenvironment of colorectal cancer.

机构信息

Center for Drug Design, University of Minnesota, Minneapolis, Minnesota, USA.

Nanotechnology Laboratory, Institute of Frontier Technology, Acharya N.G. Ranga Agricultural University, Tirupati, Andhra Pradesh, India.

出版信息

Nutr Rev. 2024 Oct 1;82(10):1420-1436. doi: 10.1093/nutrit/nuad133.

DOI:10.1093/nutrit/nuad133

PMID:37862428

Abstract

A substantial increase in colorectal cancer (CRC)-associated fatalities can be attributed to tumor recurrence and multidrug resistance. Traditional treatment options, including radio- and chemotherapy, also exhibit adverse side effects. Ancient treatment strategies that include phytochemicals like resveratrol are now widely encouraged as an alternative therapeutic option. Resveratrol is the natural polyphenolic stilbene in vegetables and fruits like grapes and apples. It inhibits CRC progression via targeting dysregulated cancer-promoting pathways, including PI3K/Akt/Kras, targeting transcription factors like NF-κB and STAT3, and an immunosuppressive tumor microenvironment. In addition, combination therapies for cancer include resveratrol as an adjuvant to decrease multidrug resistance that develops in CRC cells. The current review discusses the biology of resveratrol and explores different mechanisms of action of resveratrol in inhibiting CRC progression. Further, the detrimental role of resveratrol on the immunosuppressive tumor microenvironment of CRC has been discussed. This review illustrates clinical trials on resveratrol in different cancers, including resveratrol analogs, and their efficiency in promoting CRC inhibition.

摘要

结直肠癌（CRC）相关死亡率的大幅上升可归因于肿瘤复发和多药耐药。包括放射和化学疗法在内的传统治疗选择也具有不良反应。现在广泛鼓励包括白藜芦醇在内的植物化学物质等古代治疗策略作为替代治疗选择。白藜芦醇是葡萄和苹果等蔬菜和水果中的天然多酚类芪。它通过靶向失调的促癌途径（包括 PI3K/Akt/Kras）、靶向转录因子（如 NF-κB 和 STAT3）和免疫抑制肿瘤微环境来抑制 CRC 的进展。此外，癌症的联合治疗包括将白藜芦醇作为辅助药物来降低 CRC 细胞中产生的多药耐药性。本综述讨论了白藜芦醇的生物学特性，并探讨了白藜芦醇抑制 CRC 进展的不同作用机制。此外，还讨论了白藜芦醇对 CRC 免疫抑制肿瘤微环境的有害作用。本综述说明了不同癌症中白藜芦醇的临床试验，包括白藜芦醇类似物及其在促进 CRC 抑制方面的效率。