Department of Internal Medicine, Hebei Medical University, Shijiazhuang, China.
Department of Cardiology, Hebei General Hospital, Shijiazhuang, China.
J Int Med Res. 2023 Oct;51(10):3000605231206289. doi: 10.1177/03000605231206289.
This study assessed the antifibrotic effects of canagliflozin, with or without irbesartan, on renal injury in Dahl salt-sensitive (SS) rats fed a high-salt (HS) diet.
After the preconditioning stage, Dahl SS rats (n = 47) were divided into five experimental groups as follows: low-salt (LS, n = 7), HS (n = 10), HS with canagliflozin (n = 10), HS with irbesartan (n = 10), and HS with canagliflozin and irbesartan (n = 10).
The HS diet increased systolic blood pressure (SBP), renal fibrosis, fibrotic protein expression, and transforming growth factor-β1 (TGF-β1)/Smad2/3 pathway protein expression compared with the findings in the LS group. Irbesartan reduced SBP and slowed the loss of renal function. Canagliflozin significantly reduced body weight and renal fibrosis and suppressed the TGF-β1/Smad2/3 pathway. The combined therapy exerted better renoprotective effects on all outcome parameters.
These results indicate that canagliflozin and irbesartan exert different effects on renal injury in SS hypertensive rats, and the combined regimen could have stronger effects than either monotherapy.
本研究评估了卡格列净联合或不联合厄贝沙坦对高盐饮食喂养的 Dahl 盐敏感（SS）大鼠肾脏损伤的抗纤维化作用。
在预处理阶段后，将 47 只 Dahl SS 大鼠分为五组：低盐（LS）组（n=7）、高盐（HS）组（n=10）、HS 加卡格列净组（n=10）、HS 加厄贝沙坦组（n=10）和 HS 加卡格列净和厄贝沙坦组（n=10）。
与 LS 组相比，HS 饮食增加了收缩压（SBP）、肾脏纤维化、纤维蛋白表达以及转化生长因子-β1（TGF-β1）/Smad2/3 通路蛋白表达。厄贝沙坦降低了 SBP 并减缓了肾功能的丧失。卡格列净显著减轻了体重和肾脏纤维化，并抑制了 TGF-β1/Smad2/3 通路。联合治疗对所有终点参数都具有更好的肾脏保护作用。
这些结果表明，卡格列净和厄贝沙坦对 SS 高血压大鼠的肾脏损伤具有不同的作用，联合治疗方案可能比单一疗法具有更强的作用。
