HOMA-IR 是一种有效的非糖尿病人群非酒精性脂肪肝的生物标志物。
HOMA-IR is an effective biomarker of non-alcoholic fatty liver disease in non-diabetic population.
机构信息
Outpatient Department, Guangzhou Cadre Health Management Center, Guangzhou, China.
Clinical Laboratory, Guangzhou Cadre Health Management Center, Guangzhou, China.
出版信息
J Int Med Res. 2023 Oct;51(10):3000605231204462. doi: 10.1177/03000605231204462.
OBJECTIVES
This study aimed to investigate the correlation between homeostasis model assessment of insulin resistance (HOMA-IR) and non-alcoholic fatty liver disease (NAFLD) in the non-diabetic population and establish its diagnostic efficacy.
METHODS
This observational study involved participants divided into NAFLD and non-NAFLD groups, and baseline data were analyzed. Univariate and multivariate logistic regression analyses were used to correlate HOMA-IR with the risk of NAFLD. Receiver operating characteristic (ROC) curves were used to evaluate the diagnostic efficacy of HOMA-IR for NAFLD. Subgroup analyses of non-obese individuals were performed.
RESULTS
Overall, 2234 non-diabetic participants were included. The HOMA-IR was significantly higher in the NAFLD group than in the non-NAFLD group. Multivariate logistic regression analysis showed that HOMA-IR was a strong and independent risk factor for NAFLD after correcting for confounding factors. The area under the ROC curve (AUC) value of HOMA-IR for predicting NAFLD was 0.792. In the non-obese non-diabetic population, HOMA-IR was an independent risk factor for increased risk of lean NAFLD after correcting for confounding factors. The AUC value of HOMA-IR for predicting lean NAFLD was 0.770.
CONCLUSIONS
HOMA-IR is independently associated with the risk of NAFLD in the non-diabetic and non-obese non-diabetic populations and has good diagnostic value.
目的
本研究旨在探讨非糖尿病患者中胰岛素抵抗评估的稳态模型（HOMA-IR）与非酒精性脂肪性肝病（NAFLD）之间的相关性，并确定其诊断效能。
方法
本观察性研究纳入了分为 NAFLD 组和非 NAFLD 组的参与者，并对其基线数据进行了分析。采用单因素和多因素逻辑回归分析 HOMA-IR 与 NAFLD 风险的相关性。采用受试者工作特征（ROC）曲线评估 HOMA-IR 对 NAFLD 的诊断效能。对非肥胖个体进行亚组分析。
结果
共有 2234 例非糖尿病参与者纳入研究。NAFLD 组的 HOMA-IR 显著高于非 NAFLD 组。多因素逻辑回归分析显示，在校正混杂因素后，HOMA-IR 是 NAFLD 的一个强有力且独立的危险因素。HOMA-IR 预测 NAFLD 的 ROC 曲线下面积（AUC）值为 0.792。在非肥胖非糖尿病人群中，在校正混杂因素后，HOMA-IR 是瘦型 NAFLD 风险增加的独立危险因素。HOMA-IR 预测瘦型 NAFLD 的 AUC 值为 0.770。
结论
HOMA-IR 与非糖尿病和非肥胖非糖尿病人群中 NAFLD 的风险独立相关，具有良好的诊断价值。
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