Department of Neurology, Aneurin Bevan University Health Board, Newport, UK.
Department of Neurology, Centre Hospitalier Saint Joseph Saint Luc, Lyon, France.
Epilepsy Behav. 2023 Nov;148:109481. doi: 10.1016/j.yebeh.2023.109481. Epub 2023 Oct 19.
To assess the impact of epilepsy and antiseizure medications (ASMs) on sleep quality in people with epilepsy (PWE).
An online survey was conducted in France, Germany, Italy, Spain and the UK among PWE taking >1 ASM and matched controls. Sleep quality was evaluated using the Pittsburgh Sleep Quality Index (PSQI). Associations between sleep quality (global PSQI) and overall quality of life (QoL; assessed using the 12-Item Short Form Survey [SF-12]) and sleep quality and depressive symptoms (assessed using the Neurological Disorders Depression Inventory for Epilepsy [NDDI-E]) were also evaluated.
Overall, 500 PWE and 500 matched controls were included. PWE had significantly greater mean global PSQI scores than controls (9.32 vs 7.56; p < 0.0001), with 80% reporting a score >5 versus 66% of controls (p < 0.001). PWE experienced significantly more problems with most PSQI components than controls. Mean global PSQI scores in PWE receiving 2 versus ≥3 ASMs were 9.03 and 10.18, respectively (p < 0.004); global PSQI scores >5 were reported in 76% versus 90%, respectively (p = 0.001). Regimens containing lamotrigine or phenobarbital were associated with poorer sleep quality than those without these ASMs. In PWE, negative correlations were identified between global PSQI scores and both the SF-12 physical and mental components (Pearson's correlation coefficient [PCC], -0.61 and -0.40, respectively); NDDI-E and global PSQI scores were positively correlated (PCC, 0.6).
PWE experience significantly worse sleep quality than people without epilepsy, with some ASMs contributing to poorer sleep. QoL and physical and mental health were all affected by sleep quality in PWE.
评估癫痫和抗癫痫药物（ASMs）对癫痫患者（PWE）睡眠质量的影响。
在法国、德国、意大利、西班牙和英国，对服用>1 种 ASM 的 PWE 和匹配对照者进行了一项在线调查。使用匹兹堡睡眠质量指数（PSQI）评估睡眠质量。还评估了睡眠质量（整体 PSQI）与整体生活质量（使用 12 项简明健康调查问卷 [SF-12] 评估）以及睡眠质量与抑郁症状（使用癫痫神经障碍抑郁量表 [NDDI-E] 评估）之间的关系。
总体而言，纳入了 500 名 PWE 和 500 名匹配对照者。PWE 的平均整体 PSQI 评分明显高于对照者（9.32 对 7.56；p<0.0001），80%的人报告评分>5 分，而对照者为 66%（p<0.001）。与对照者相比，PWE 在大多数 PSQI 成分上的问题更为严重。接受 2 种 ASM 与接受≥3 种 ASM 的 PWE 的平均整体 PSQI 评分分别为 9.03 和 10.18（p<0.004）；分别有 76%和 90%的人报告评分>5 分（p=0.001）。含有拉莫三嗪或苯巴比妥的方案与无这些 ASM 的方案相比，睡眠质量较差。在 PWE 中，整体 PSQI 评分与 SF-12 身体和心理成分之间存在负相关（Pearson 相关系数 [PCC]，分别为-0.61 和-0.40）；NDDI-E 和整体 PSQI 评分呈正相关（PCC，0.6）。
PWE 的睡眠质量明显差于无癫痫的人群，某些 ASM 会导致睡眠质量更差。在 PWE 中，生活质量和身体及心理健康均受到睡眠质量的影响。
